Abstract
Although it has been assumed for many years that DDP accumulates into cells by means of passive diffusion (1), this has been supported only by unconvincing and conflicting reports (2,3). Recently, it has become apparent that decreased DDP uptake is a characteristic of a variety of DDP-resistant cell types. We have reported preliminary studies that two DDP-resistant human ovarian carcinoma cell lines have decreased DDP uptake (4,5). Other workers have also described decreased DDP uptake in DDP-resistant L1210 cells, CHO cells, and SCC-25 human head and neck squamous carcinoma cells (6–11). Characterization of the mechanism(s) of DDP uptake and how it has changed in DDP-resistant cells is clearly an important issue for understanding not only DDP-resistance, but the cellular pharmacokinetics of DDP in general.
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© 1988 Martinus Nijhoff Publishing, Boston
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Andrews, P.A., Mann, S.C., Velury, S., Howell, S.B. (1988). Cisplatin Uptake Mediated Cisplatin-Resistance in Human Ovarian Carcinoma Cells. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_26
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DOI: https://doi.org/10.1007/978-1-4613-1717-3_26
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