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Measles

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Clinical and Molecular Aspects of Neurotropic Virus Infection

Part of the book series: Developments in Medical Virology ((DIMV,volume 5))

Abstract

Although preventable through vaccination, measles continues to be an important cause of childhood morbidity and mortality. Systemic complications take the greatest toll, but there are also diverse neurological complications of this common viral infection which can be separated into three distinct syndromes. Postmeasles encephalomyelitis is an acute demyelinating disease which follows measles and has an allergic or autoimmune pathogenesis. Subacute sclerosing panencephalitis is a slowly progressive infection of the brain caused by a defective replication of measles virus accumulating in brain cells despite an apparently normal immune response. Subacute inclusion body encephalitis of the immunosuppressed occurs when measles infects the T cell deficient host who allows unrestrained replication of the virus. In addition to these well established syndromes, the relationship of measles to multiple sclerosis is summarized.

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Author information

Authors and Affiliations

  1. Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    T. R. Moench

  2. Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    T. R. Moench

  3. Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    R. T. Johnson

  4. Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    R. T. Johnson

Authors
  1. T. R. Moench
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  2. R. T. Johnson
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Editor information

Editors and Affiliations

  1. Department of Neurology, University of Colorado Health Sciences Center, Denver, CO, 80262, USA

    Donald H. Gilden M.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Neurology, Northwestern University Medical School, Chicago, Illinois, 60611, USA

    Howard L. Lipton M.D. (Professor and Acting Chairman) (Professor and Acting Chairman)

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© 1989 Kluwer Academic Publishers

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Moench, T.R., Johnson, R.T. (1989). Measles. In: Gilden, D.H., Lipton, H.L. (eds) Clinical and Molecular Aspects of Neurotropic Virus Infection. Developments in Medical Virology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1675-6_7

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  • DOI: https://doi.org/10.1007/978-1-4613-1675-6_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8935-7

  • Online ISBN: 978-1-4613-1675-6

  • eBook Packages: Springer Book Archive

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