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The ras family of oncogenes

  • Chapter
Oncogenes

Part of the book series: Cancer Treatment and Research ((CTAR,volume 47))

Abstract

The first evidence implicating a role for the cellular ras genes in oncogenesis came from studies of the highly oncogenic RNA tumor viruses [1–4]. The cellular ras genes were first identified to be the cellular counterparts to the viral genes responsible for the oncogenic properties of Harvey (v-H-ras) and Kirsten (v-K-ras) murine sarcoma viruses [5,6]. Further interest in the role of cellular ras genes in carcinogenesis exploded in 1982, when the first human transforming genes were identified as activated cellular counterparts of viral ras genes [7–9]. Over the past six years, an enormous research effort has centered on characterizing the biochemistry and biology of these potential human oncogenes. Of the 40 or so cellular oncogenes that have been identified to date, the cellular ras genes have demonstrated the strongest association with human carcinogenesis. The frequent identification of activated ras genes in a wide variety of human neoplasms has provided strong circumstantial evidence for the role of these genes in the malignant process. Consequently, it is generally believed that determining the mechanism of action of ras will contribute significantly to our understanding of the molecular mechanisms of human carcinogenesis.

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Authors
  1. Channing J. Der
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Editors and Affiliations

  1. Cancer Research Institute, University of California, San Francisco, USA

    Christopher Benz

  2. Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    Edison Liu

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© 1989 Kluwer Academic Publishers

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Der, C.J. (1989). The ras family of oncogenes. In: Benz, C., Liu, E. (eds) Oncogenes. Cancer Treatment and Research, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1599-5_4

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  • DOI: https://doi.org/10.1007/978-1-4613-1599-5_4

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