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Bifunctional chelating agents for radiometal-labeled monoclonal antibodies

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Cancer Imaging with Radiolabeled Antibodies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 51))

Abstract

Recently there has been a great deal of interest in attaching metal ions to proteins. Since a variety of metal ions possess interesting chemical, physical, nuclear, and magnetic properties, they can be employed to probe the behavior of biologic systems. For example, fluorescent-labeled proteins, proteins containing paramagnetic chelates, and proteins bound to photosensitive metal chelates have been studied [1]. When the metal is radioactive and the protein is an antibody that has high specficity for tumors, the resultant chelate-antibody conjugate can be employed for cancer diagnosis. Monoclonal antibodies that possess a high affinity for tumor-associated antigens can now be prepared due to the technique developed by Kohler and Milstein [2]. By attaching a radionuclide to such a monoclonal antibody of predetermined specificity, one can selectively localize the radioactivity at tumor sites. This principle has been employed in developing new pharmaceuticals for use in radioimmuno-diagnosis and, in certain cases, radioimmunotherapy [3,4]. In this review we will briefly examine the chemical aspects of bifunctional chelating agents for linking radiometals to monoclonal antibodies.

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Authors
  1. Ramaswamy Subramanian
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  2. Claude F. Meares
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Editors and Affiliations

  1. Center for Molecular Medicine and Immunology, University of Medicine and Dentistry of New Jersey, 1 Bruce St., Newark, New Jersey, 07103, USA

    David M. Goldenberg Sc.D., M.D.

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© 1990 Kluwer Academic Publishers

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Subramanian, R., Meares, C.F. (1990). Bifunctional chelating agents for radiometal-labeled monoclonal antibodies. In: Goldenberg, D.M. (eds) Cancer Imaging with Radiolabeled Antibodies. Cancer Treatment and Research, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1497-4_9

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  • DOI: https://doi.org/10.1007/978-1-4613-1497-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8805-3

  • Online ISBN: 978-1-4613-1497-4

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