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Protein kinase C and breast cancer

  • Chapter
Mammary Tumor Cell Cycle, Differentiation, and Metastasis

Part of the book series: Cancer Treatment and Research ((CTAR,volume 83))

Abstract

Protein kinase C (PKC) was first described by Nishizuka’s laboratory in 1977 as a proteolytically activated kinase [1–3]. Subsequent work has established the importance of PKC activity in a multitude of cell functions that regulate growth and differentiation in a variety of cell types [4,5]. More recently, molecular cloning approaches have established that PKC is actually a family of closely related isoenzymes [6,7]. These include the calcium-dependent isoenzymes a, βI, βII, and γ; the calcium-independent isoenzymes δ, ε, η, θ, and µ; and the atypical isoenzymes, ζ and i(λ) (Table 1). These enzymes are the products of distinct genes, with the exception of PKC βI and βII, which are derived from alternative splicing of a single gene. The PKC enzymes are structurally quite similar. They are composed of a single polypeptide chain with a regulatory domain at the amino terminus and a catalytic domain at the carboxyl terminus. The isoenzymes can be divided into four regions that are conserved across isoenzymes (C1-C4) and five regions that vary between isoenzymes but are conserved within the isoenzyme across species (V1-V5) [9,10].

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Authors
  1. Nancy E. Davidson
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  2. M. John Kennedy
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Editor information

Editors and Affiliations

  1. Departments of Cell Biology and Pharmacology, Lombardi Cancer Center, The Research Building, 3970 Reservoir Road, 20007, Washington, DC, USA

    Robert B. Dickson PHD

  2. Departments of Medicine and Pharmacology, Lombardi Cancer Center, The Research Building, 20007, 3970 Reservoir Road, Washington, CD, USA

    Marc E. Lippman MD

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© 1996 Kluwer Academic Publishers

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Davidson, N.E., Kennedy, M.J. (1996). Protein kinase C and breast cancer. In: Dickson, R.B., Lippman, M.E. (eds) Mammary Tumor Cell Cycle, Differentiation, and Metastasis. Cancer Treatment and Research, vol 83. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1259-8_5

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  • DOI: https://doi.org/10.1007/978-1-4613-1259-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8536-6

  • Online ISBN: 978-1-4613-1259-8

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