Abstract
Three major pathways exist for the dissemination of ovarian malignancy: metastases via the bloodstream, metastases via lymphatic channels, and spread of cancer cells throughout the abdomen and pelvis as a result of rupture of the ovarian capsule. Full-thickness penetration with free perforation of cancer through the ovarian capsule and dissemination of cancer emboli in the peritoneal cavity occurs in a great majority of ovarian cancer patients prior to the diagnosis of this disease [1]. Once tumor cells are free within the peritoneal cavity, distribution may proceed by three different mechanisms: random distribution, redistribution, and tumor cell entrapment [2]. Random distribution and redistribution may occur at any time and are dependent on cell surface properties of the intraabdominal cancer emboli. Tumor cell entrapment is seen at inflammatory sites; it occurs most frequently within tissues that are subjected to surgical trauma, is not dependent on adherence properties of the cancer cell surface and manifests itself as recurrent cancer within scar tissue and within adhesions [3,4].
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References
Young RC, Fuks Z, Hoskins, WJ. Cancer of the ovary. In DeVita VT, Hellman S, Rosenburg SA, eds. Cancer: Principles and Practice of Oncology, 3rd ed. Philadelphia: JB Lippincott, 1989, pp 1162–1196.
Sugarbaker PH. Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology. In Sugarbaker PH, ed. Peritoneal Carcinomatosis: Principles of Management. Norwell, MA: Kluwer Academic, 1995, pp 79–100.
Sugarbaker PH, Cunliffe WJ, Belliveau JF, deBruijn EA, Graves T, Mullins, RE, Schlag P. Rationale for integrating early postoperative intraperitoneal chemotherapy (EPIC) into the surgical treatment of gastrointestinal cancer. Semin Oncol 1989;16:83–97.
Sugarbaker PH Peritoneal carcinomatosis: natural history and rational therapeutic interventions using intraperitoneal chemotherapy. In Sugarbaker PH, ed Peritoneal Carcinomatosis: Drugs and Diseases. Norwell, MA: Kluwer Academic Publishers, 1996, pp 149–168.
Steller EP. The peritoneal cancer index. In Enhancement and Abrogation. Rotterdam: Krips Repo Meppel, 1991, pp 44–55.
Jacquet P, Jelinek JS, Steves MA, Sugarbaker PH. Evaluation of computed tomography in patients with peritoneal carcinomatosis. Cancer 1993;72:1631–1636.
Jacquet PJ, Sugarbaker PH. Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis. In Sugarbaker PH, ed Peritoneal Carcinomatosis: Principles of Management. Norwell, MA: Kluwer Academic, 1995, pp 359–373.
Woolson RF. Statistical Methods for the Analysis of Biomedical Data. New York: John Wiley, 1987.
Sugarbaker PH. Complete parietal and visceral peritoneotomy of the pelvis for advanced primary and recurrent ovarian cancer. In Sugarbaker PH, ed Peritoneal Carcinomatosis: Drugs and Diseases. Norwell, MA: Kluwer Academic, 1995, pp 75–87.
Sugarbaker PH, Jablonski KA. Prognostic features of 51 colorectal and 130 appendiceal cancer patients with peritoneal carcinomatosis treated by cytoreductive surgery and intraperitoneal chemotherapy. Ann Surg 1995;221:124–132.
Fujimoto S, Shrestha RD, Kokubun M, Ohta M, Takahashi M, Kobayashi K, Kiuchi S, Okui K, Miyoshi T, Arimizu N, Takamizawa H. Intraperitoneal hyperthermic perfusion combined with surgery effective for gastric cancer patients with peritoneal seeding. Ann Surg 1988;208:36–41.
Yonemura Y, Fujimura T, Fushida S, Takegawa S, Kamata T, Katayama K, Kosaka T, Yamaguchi A, Miwa K, Miyazaki I. Hyperthermo-chemotherapy combined with cytoreductive surgery for the treatment of gastric cancer with peritoneal dissemination. World J Surg 1991;15:530–536.
Sporn MB, Roberts AB. Peptide growth factors and inflammation, tissue repair, and cancer. J Clin Invest 1986;78:329–332.
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© 1996 Kluwer Academic Publishers, Boston
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Sugarbaker, T.A., Chang, D., Koslowe, P., Sugarbaker, P.H. (1996). Pathobiology of peritoneal carcinomatosis from ovarian malignancy. In: Sugarbaker, P.H. (eds) Peritoneal Carcinomatosis: Drugs and Diseases. Cancer Treatment and Research, vol 81. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1245-1_7
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DOI: https://doi.org/10.1007/978-1-4613-1245-1_7
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