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Intimal Responses to Shear Stress, Hypercholesterolemia, and Hypertension

Studies in the Rat Aorta

  • Chapter
Endothelial Cell Biology in Health and Disease

Abstract

From the perspective of pathology, the three most common challenges to the intima of larger arteries are local disturbances of flow, hypercholesterolemia, and hypertension. We have studied all three in one experimental system, the aorta of the rat. This chapter is a critical summary of these studies. As an introduction, we will examine some relevant features of our experimental model.

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, 01655, USA

    C. Majno, T. Zand, J. J. Nunnari, M. C. Kowala & I. Joris

Authors
  1. C. Majno
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  2. T. Zand
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  3. J. J. Nunnari
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  4. M. C. Kowala
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  5. I. Joris
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Editor information

Editors and Affiliations

  1. Institute of Cellular Biology and Pathology, Bucharest, Romania

    Nicolae Simionescu  & Maya Simionescu  & 

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© 1988 Plenum Press, New York

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Majno, C., Zand, T., Nunnari, J.J., Kowala, M.C., Joris, I. (1988). Intimal Responses to Shear Stress, Hypercholesterolemia, and Hypertension. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Biology in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0937-6_16

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  • DOI: https://doi.org/10.1007/978-1-4613-0937-6_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8254-9

  • Online ISBN: 978-1-4613-0937-6

  • eBook Packages: Springer Book Archive

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