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Vascular Endothelium

Functional Modulation at the Blood Interface

  • Chapter
Endothelial Cell Biology in Health and Disease

Abstract

Vascular endothelium, in its simplest conception, is an anatomical barrier—a partition that separates the intravascular compartment from the rest of the cells and tissues of the body. From a functional viewpoint, however, there is ample evidence that the cells comprising this interface are dynamic partners in multiple, complex interactions involving macromolecular and cellular constituents of blood as well as vessel wall components, such as smooth muscle and extracellular matrix. As the contents of this volume illustrate, the list of vital functions of vascular endothelium is diverse and ever-increasing. Furthermore, it is apparent that the functional status of the vascular lining is as important as its anatomical integrity.1,2 This is especially true since many of the relevant cell surface and metabolic properties of endothelium are inducible, rather than constitutive, and thus may be subject to physiologic regulation and potential pathologic derangement.

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  1. Vascular Research Division, Department of Pathology, Brigham and Wome’s Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA

    Michael A. Gimbrone Jr. & Michael P. Bevilacqua

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  1. Michael A. Gimbrone Jr.
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  1. Institute of Cellular Biology and Pathology, Bucharest, Romania

    Nicolae Simionescu  & Maya Simionescu  & 

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Gimbrone, M.A., Bevilacqua, M.P. (1988). Vascular Endothelium. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Biology in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0937-6_12

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  • DOI: https://doi.org/10.1007/978-1-4613-0937-6_12

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