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Excitotoxins and Animal “Models” of Human Disease

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Recent Advances in Nervous System Toxicology

Part of the book series: NATO ASI Series ((NSSA,volume 100))

Abstract

Glutamate, aspartate and a number of structurally related amino acids possess the capacity not only to excite neurons in the CNS, but also to bring about their destruction if administered at a sufficiently high concentration. The neurotoxic effects are diverse and not yet well understood. Nevertheless, they are being exploited by neuroscientists as a means of providing much new information about the operation of neuronal systems. This review will be concerned with a brief description of some of the excitatory and neurotoxic amino acids that have been investigated to date, their diverse modes of action and their use to produce some animal models of human disease.

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  1. Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada

    Edith G. McGeer & Patrick L. McGeer

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  1. Edith G. McGeer
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  1. Institute of Pharmacology and Pharmacognosy, Milan, Italy

    Corrado L. Galli

  2. Institute of Pharmacology, Pavia, Italy

    Luigi Manzo

  3. Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA

    Peter S. Spencer

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McGeer, E.G., McGeer, P.L. (1988). Excitotoxins and Animal “Models” of Human Disease. In: Galli, C.L., Manzo, L., Spencer, P.S. (eds) Recent Advances in Nervous System Toxicology. NATO ASI Series, vol 100. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0887-4_7

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