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Catalytic Antibodies

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Biomimetic Polymers

Abstract

Attention has focused on the mammalian immune system as a source of highly specific, tailored catalysts. The construction of enzyme-like immunoglobulins involves synthesizing compounds that mimic the transition state structure of a particular reaction, eliciting an immune response against such substances, and screening the resulting antibodies for the desired activity and specificity. The recent and rapid progress that has been made in generating catalytic antibodies for diverse chemical transformations, from hydrolytic to concerted pericyclic processes, is reviewed.

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Authors and Affiliations

  1. Department of Molecular Biology, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Donald Hilvert

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  1. Donald Hilvert
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Editor information

Editors and Affiliations

  1. Dept. of Chemistry, Youngstown State University, Youngstown, Ohio, 44555, USA

    Charles G. Gebelein

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© 1990 Plenum Press, New York

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Hilvert, D. (1990). Catalytic Antibodies. In: Gebelein, C.G. (eds) Biomimetic Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0657-3_6

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  • DOI: https://doi.org/10.1007/978-1-4613-0657-3_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7913-6

  • Online ISBN: 978-1-4613-0657-3

  • eBook Packages: Springer Book Archive

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