Abstract
Studies in experimental animals (usually mice or rats) show that dietary restriction (DR) of caloric intake, but without essential nutrient malnutrition, generates many desirable biological outcomes (see Holehan and Merry, 1986; Masoro, 1988; Walford et al., 1987; Weindruch and Walford, 1988). In rodents, caloric restrictions of 30–70% reduce the incidence and delay the onset of many late-life diseases. The rates of change for almost all the age-sensitive biological parameters tested to date are slowed by DR. These effects of DR on rodents are unmatched by competitor methods. As a result, rodents subjected to DR are widely viewed as the best model available to study the biology of decelerated aging in homeothermic vertebrates.
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© 1990 Plenum Press, New York
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Weindruch, R. (1990). Caloric Restriction and Longevity. In: Goldstein, A.L. (eds) Biomedical Advances in Aging. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0513-2_29
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DOI: https://doi.org/10.1007/978-1-4613-0513-2_29
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