Abstract
Drugs acting on muscarinic cholinergic receptors, dopaminergic D-1, D-2, D-3, D-4 receptors and glutamatergic N-Methyl-D-Aspartate (NMDA) receptors are known to exert major influences on motor functions by an action on the Basal Ganglia. This strikingly contrasts with the elusiveness of the influences of these receptors on the function of striatal neurons as measured by electrophysiological methods that readily demonstrate the action of classical neurotransmitter receptors such as those of the glutamate/AMPA or GABA-A type. For example, only in recent times, almost 30 years after the appraisal of dopamine (DA) deficiency as a causal factor in Parkinson’s disease, the electrophysiological actions of DA at the single cell level are starting to be unraveled (Calabresi et al., 1987; Lacey et al, 1987; Kitai and Surmeier, 1993). The reason for the elusive nature of dopaminergic, muscarinic and NMDA transmission might be the fact that they do not directly trigger or inhibit action potentials but rather gate or modulate their generation by “fast” neurotransmitter receptors.
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Chiara, G.D., Morelli, M. (1994). Acetylcholine, Dopamine and NMDA Transmission in the Caudate-Putamen: Their Interaction and Function as a Striatal Modulatory System. In: Percheron, G., McKenzie, J.S., Féger, J. (eds) The Basal Ganglia IV. Advances in Behavioral Biology, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0485-2_51
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