Abstract
Yamamoto and Hayaishi (1967) first reported the presence of indoleamine 2,3-di- oxygenase [IDO; indoleamine: oxygen 2,3-oxidoreductase (decyclizing)] in rabbit intestine. This enzyme was also later found in mice (Yoshida et al., 1980), rats (Cook et al, 1980) and humans (Yamazaki et al., 1985), in which the highest activity was observed in the placenta, followed by lung, small intestine, and various other organs. IDO was markedly induced by various pathogens such as viruses and bacterial endotoxins (Yoshida and Hayaishi, 1978; Yoshida et al., 1979). Induction appears to be mediated by interferon-y and causes a marked increase in tryptophan catabolism (Takikawa et al., 1986). Enzyme induction was also observed by intraperitoneal transplantation of tumor cells to allogeneic strains of mice (Yoshida et al., 1984). A marked increase in IDO activity was also found in human lungs bearing cancer (Yasui et al., 1986)
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Reference
Benassi C.A., Perissinotto B., and Allegri G., 1963, The metabolism of tryptophan in patients with bladder cancer and other urological diseases, Clin ChimActa, 8: 822.
Cook J.S., Pogson C.I., Smith S.A., 1980, Indoleamine 2,3-dioxygenase: a new, rapid, sensitive radiometric assay and its application to the study of the enzyme in rat tissues, Biochem J., 189: 461.
DeGeorge F.V. and Brown R.R., 1970, Difference in tryptophan metabolism between breast cancer patients with and without cancer at other sites, Cancer26: 767.
Gailani S., Ezdinli E., Nussbaum A., Silvernail P., and Elias E.G., 1974, Studies on tryptophan metabolism in patients with lymphoma, Cancer Res., 34: 1664.
Lowry O.H., Rosebrough N.J., Farr A.L. and Randall R.J., 1951, Protein measurement with the Folin phenol reagent, J Biol Chem., 193: 265.
Musajo L., Benassi C.A., 1964, Aspects of disorders of the kynurenine pathway of tryptophan metabolism in man, Adv Clin Chem., 7: 63.
Naito J., Ishiguro I., Nagamura Y., and Ogawa H., 1991, Rat skin tryptophan 2,3-dioxygenase, in Kinurenine and Serotonin Pathways, R. Schwarcz et al., eds., Plenum Press, New York, p. 527.
Nitti D., Lise M., Costa C., Cardin de Stefani E.L., Allegri G., 1990, L-Tryptophan metabolism in human cutaneous malignant melanoma, Giorn lt Chim Clin., 15: 211.
Quagliarello E., Tancredi F., Fedele L., and Saccone C., 1961, Tryptophan-nicotinic acid metabolism in patients with tumors of the bladder. Changes in the excretory products after treatment with nicotinamide and vitamin B6, Brit J Cancer, 15: 367.
Shimizu T., Nomiyama S., Hirata F., and Hayaishi O., 1978, Idoleamine 2,3-dioxygenase, purification and some properties, J Biol Chem.253: 4700.
Takikawa O., Yoshida R., Kido R., and Hayaishi O., 1986, Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase, J Biol Chem., 261: 3648.
Yamamoto S. and Hayaishi O., 1967, Tryptophan pyrrolase of rabbit intestine, J Biol Chem,, 242: 5260.
Yamazaki F., Kuroiwa T., Takikawa O., and Kido R, 1985, Human indolyl-amine 2,3-dioxygenase, its tissue distribution, and characterization of the placental enzyme, Biochem J., 230: 635.
Yasui H., Takai K., Yoshida R., and Hayaishi O., 1986, Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients, Proc Natl Acad Set, USA, 83: 6622.
Yoshida R. and Hayaishi O., 1978, Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide, Proc Natl Acad Sci USA, 75: 3998.
Yoshida R., Urade Y., Tokuda. M, and Hayaishi O., 1979, Induction of indoleamine 2,3-dioxygenase in mouse lung during infection, Proc Natl Acad Sci.USA, 76: 4084.
Yoshida R., Nukiwa T., Watanabe Y., Fujiwara M., Hirata F. and Hayaishi O., 1980, Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and epididymis of mice, Arch Biochem Biophys.203: 343.
Yoshida R., Takikawa O., Yasui H., Hayaishi O., and Yasuhira K., 1984, Role of indoleamine 2,3-dioxygenase in the defense mechanism against tumor growth, in Progress in Tryptophan and Serotonin Research, Walter de Gruyter ed., Berlin, p. 513.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Plenum Press, New York
About this chapter
Cite this chapter
Bertazzo, A., Costa, C.V.L., Lise, M., Nitti, D., Allegri, G. (1996). Occurrence of Indoleamine 2,3-Dioxygenase in Human Cutaneous Malignant Melanoma. In: Filippini, G.A., Costa, C.V.L., Bertazzo, A. (eds) Recent Advances in Tryptophan Research. Advances in Experimental Medicine and Biology, vol 398. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0381-7_80
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0381-7_80
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-8026-9
Online ISBN: 978-1-4613-0381-7
eBook Packages: Springer Book Archive