Abstract
We have reported that administration of tryptophan (Trp) usually cures hepatic injury caused by carbontetrachrolide but occasionally causes aggravation of it and the serum concentration of kynurenine (Kyn) in hepatic injured mouse increases even though the low activity of tryptophandioxygenase (TDO) in hepatic injury. We will discuss that the accel¬eration of Kyn generation would be caused by macrophage(MP) and some Trp metabolites may play an important role in both the cure of hepatic injury or aggravation of it.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Plenum Press, New York
About this chapter
Cite this chapter
Nagamura, Y., Uesugi, K., Naito, J., Saitoh, K., Noma, A., Ishiguro, I. (1996). Macrophages Modulate Liver Cell Function via Tryptophan Metabolites. In: Filippini, G.A., Costa, C.V.L., Bertazzo, A. (eds) Recent Advances in Tryptophan Research. Advances in Experimental Medicine and Biology, vol 398. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0381-7_59
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0381-7_59
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-8026-9
Online ISBN: 978-1-4613-0381-7
eBook Packages: Springer Book Archive