Abstract
Investigation of the mechanisms regulating the proliferation and differentiation of hemic tissue remains an important area of research despite the many accomplishments in this field. Both humoral and cellular systems have been implicated in many of the maturational pathways, from the pluripotent hemopoietic stem cell (HSC) to mature cellular elements of the blood. Thus, hormones, such as erythropoietin, are known to interact with erythroid precursor elements in culture to eventually differentiate into circulating red blood cells (RBC) (1,19). More recently, we have described a system (11,17,18) in which cells carrying the well-known surface antigen associated with lymphocytes (the theta- or THY-1 antigen) may regulate the normal proliferation of stem cells and erythroid precursors in the anemic W/W v mouse. Thus, bone marrow treated in vitro with alloantisera (CBA thymocytes given to AKR mice) plus complement and transplanted into anemic mice produces sufficient numbers of macroscopic colonies on the surface of spleens, but these colonies are predominantly committed granulocyte precursor elements with no potential to produce stem cells (17,18).
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Sharkis, S.J., Ahmed, A., Sensenbrenner, L.L., Jedrzejczak, W.W., Goldstein, A.L., Sell, K.W. (1978). The Regulation of Hemopoiesis: Effect of Thymosin or Thymocytes in a Diffusion Chamber. In: Baum, S.J., Ledney, G.D. (eds) Experimental Hematology Today 1978. Experimental Hematology Today, vol 1978. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6304-3_3
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