Abstract
The “trace” amines such as 2-phenylethylamine, m-and p-tyramine and tryptamine accumulate in brain after administration of monoamine oxidase inhibitor antidepressant drugs (Boulton and Juorio, 1982). Accumulated quantities of these substances, in addition to having effects by themselves, may have important interactions with neurotransmitter receptor systems. In the study reported here we have examined the in vitro interactions of these trace amines with serotonin (5-hydroxytryptamine; 5-HT) recognition sites (5-HT1 and 5-HT2) of rat cerebral cortex. Modulation of serotonin receptors by the central neurotransmitter, norepinephrine, has been recognized recently (Scott and Crews, 1985); the trace amines also may have important interactions with the serotonin receptors.
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References
Boulton A. A. and Juorio A. V. (1982) Brain trace amines, in Handbook of Neurochemistry (A. Lajtha, ed.), vol. 1, pp. 184–222. Plenum Press, New York.
Dewhurst W. G. and Marley E. (1965) The effect of alpha methyl derivatives of noradrenaline, phenyl ethyl amine and tryptamine on the central nervous system of the chicken. Brit. J. Pharmacol. 3: 682–704.
Glowinski J. and Iversen L. L. (1966) Regional studies of catecholamines in the rat brain. 1. The disposition of [3H] norepinephrine, [3H] dopamine and [3H] dopa in various regions of the brain. J. Neurochem. 13: 655–669.
Leysen J. E. and Tollenaere J. P. (1982) Biochemical models for serotonin receptors. Ann. Rept. Med. Chem. 17: 1–10.
Locock R. A., Baker G. B., Coutts R. T. and Dewhurst W. G. (1984) Displacement of serotonin from binding sites in rat cortex: Effects of biogenic “trace” amines. Prog. Neuropsychopharmacol. & Biol. Psychiat.8: 701–704.
Martin L. L. and Sanders-Bush E. (1982) Comparison of the pharmacological characteristics of 5-HT1 and 5-HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release. Arch. Pharmacol. 321: 165–170.
Nelson D. L., Week B. and Taylor W. (1983) Discrimination of heterogeneous serotonin receptors by indolealkyl-amines, in CNS Receptors-From Molecular Pharmacology to Behaviour (P. Mandel and F. V. DeFeudis, eds.), pp. 337–347. Raven Press, New York.
Scott J. A. and Crews F. T. (1985) Increases in serotonin2 receptor density in rat cerebral cortexslices by stimulation of beta-adrenergic receptors. Biochem. Pharmacol. 34: 1585–1588
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Locock, R.A., Baker, G.B., Coutts, R.T., Dewhurst, W.G., Liu, T.T.S. (1985). Interaction of Trace Amines with Serotonin Recognition Sites in Rat Brain. In: Boulton, A.A., Maitre, L., Bieck, P.R., Riederer, P. (eds) Neuropsychopharmacology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5010-4_18
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DOI: https://doi.org/10.1007/978-1-4612-5010-4_18
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