Abstract
Procedures are described for assessing the abuse liability of drugs and their potential to produce physiological dependence in human volunteers. Abuse liability of a drug is determined by showing that a drug (a) is psychoactive, (b) produces euphoria, and (c) serves as a reinforcer. The strategies currently used to collect such data include objective assessment of euphoria by use of structured questionnaires and the intravenous drug self-administration paradigm. Dependence potential is determined by the ability of a drug to produce withdrawal when chronic administration is terminated (direct addiction procedure) or to block withdrawal when substituted for a drug known to produce physiological dependence (substitution procedure). Physiological dependence is viewed as a concomitant factor in the abuse potential of a drug, but not the cardinal indicator.
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Henningfield, J.E., Johnson, R.E., Jasinski, D.R. (1987). Clinical Procedures for the Assessment of Abuse Potential. In: Bozarth, M.A. (eds) Methods of Assessing the Reinforcing Properties of Abused Drugs. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4812-5_27
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