Abstract
Use of the selective irreversible monoamine oxidase (MAO) inhibitors clorgyline and (-)-deprenyl (selegiline) have allowed the distribution and specificities of the two forms of the enzyme, MAO-A and MAO-B, to be determined in a number of tissues and species (for reviews, see Fowler and Tipton, 1984; Tipton, 1986). The distributions and specificities of MAO-A and -B in a number of human tissue homogenates are surrmarised in Table 1.
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References
Arai Y., Stenström, A. and Oreland L, (1985). The effects of age on intra- and extraneuronal monoamine oxidase -A and -B activities in the rat brain. Biogenic Amines 2, 65–71.
Ask A.-L., Fagervall I. and Ross S.B. (1983). Selective inhibition of monoamine oxidase in monoaminergic neurons in the rat brain. Naunyn-Schmiedeberg’s Arch. Pharmacol. 324, 79–87.
Bieck P.R., Nilsson E., Schick C., Waldmeier P.C. and Lauber J. (1984). Urinary excretion of tryptamine in comparison to normetanephrine and beta-phenylethylamine in human volunteers after subchronic treatment with different monoamine oxidase inhibitors, in Neurobiology of the Trace Amines (Boulton A.A., Baker G.B., Dewhurst W.G. and Sandler M. eds), pp 525–539. Humana Press, Clifton.
Blackwell B. and Marley E. (1966). Interactions of cheese and its constituents with monoamine oxidase inhibitors. Br. J. Pharmacol. Chemother. 26, 121–141.
Demarest K.T., Smith D.J. and Azzaro A.J. (1980). The presence of the type A form of monoamine oxidase within nigrostriatal dopamine-containing neurones. J. PHarmacol. exp. Ther. 215, 461–468.
Fagervall I. and Ross S.B. (1986). A and B forms of monoamine oxidase within the monoaminergic neurones of the rat brain. J. Neurochem. 47, 569–576.
Fowler C.J. and Ross S.B. (1984). Selective inhibitors of monoamine oxidase A and B: biochemical, pharmacological and clinical properties. Med. Res. rev. 4, 323–358.
Fowler C.J. and Tipton K.F. (1984). On the substrate specificities of the two forms of monoamine oxidase. J. PHarm. Pharmacol. 36, 111–115.
Fowler C.J., Magnussen O. and Ross S.B. (1984). Intra- and extraneuronal monoamine oxidase. Blood Vess. 21, 126–131.
Hallman H., Sundstrom E. and Jonsson G. (1984). Effects of the noradrenaline neurotoxin DSP4 on monoamine neurons and their transmitter turnover in rat CNS. J. Neural Transm. 60, 89–102.
Hasan F., McCrodden J.M. and Tipton K.F. (1987). The involvement of intestinal monoamine oxidase in the transport and metabolism of tyramine J. Neural Transm., in press.
Heikkila R.E., Manzino L., Cabbat F.S. and Duvoisin R.C. (1984). Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl - 1,2, 3,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature (Lond). 311, 467–469.
Javitch J.A., D’Amato R.J., Strittmatter S.M. and Snyder S.H. (1985). Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. USA 82 2173–2177.
Johnstone M.V. and Coyle J.T. (1979). Histological and neurochemical effects’ of fetal treatment with methy1-azoxymethanol on rat neocortex in adulthood. Brain Res. 170, 135–155.
Jonsson G. and Hallman H. (1982). Effects of prenatal methylazoxymethanol treatment on the development of central monoamine neurons. Dev. Brain Res. 2, 513–520.
Lipper S., Murphy D.L., Slater S. and Buchsbaum M.S. (1979). Comparative behavioural effects on clorgyline and pargyline in man. A preliminary evaluation. Psycho-pharmacology 62, 123–128.
Nicklas W.J., Vyas I. and Heikkila R.E. (1985). Inhibition of NADH-linked oxidation in brain mitochondria by l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Life Sci. 36, 2503–2508.
O’Carroll A.-M., Fowler C.J., Phillips J.P., Tobbia I. and Tipton K.F. (1983). The deamination of dopamine by human brain monoamine oxidase. Specificity for the two enzyme forms in seven brain regions. Naunyn-Schmiedeberg’s Arch.Pharmacol. 322, 198–202.
O’Carroll A.-M., Bardsley M.E. and Tipton K.F. (1986). The oxidation of adrenaline and noradrenaline by the two forms of monoamine oxidase from human and rat brain. Neurochem. Int. 8, 493–500.
O’Carroll A.-M., Tipton K.F., Sullivan J.P., Fowler C.J. and Ross S.B. (1987). Intra- and extrasynaptosomal deamination of dopamine and noradrenaline by the two forms of human brain monoamine oxidase. Implications for the neurotoxicity of N-methyl - 1,2,3,6-tetrahydro-pyridine in man. Biogenic Amines 4, 47–60.
Oreland L., Arai Y., Stenstrom A. and Fowler C.J. (1983). Monoamine oxidase activity and localisation in brain and the activity in relation to psychiatric disorders. Mod. Probl. Pharmacopsychiat. 19, 246–254.
Pare C.M.B. (1984). Clinical studies with monoamine oxidase inhibitors and tricyclic antidepressants in Monoamine Oxidase and Disease (Tipton K.F., Dostert P. and Strolin Benedetti M, eds), pp. 469–478. Academic Press, London
Ramsay R.R., Dadgar J., Trevor A.J. and Singer T.P. (1986). Energy-driven uptake of N-methyl-4-phenylpyridine in brain mitochondria mediates the neurotoxicity of MPTP. Life Sci. 39, 581–588.
Ross S.B. (1987). Distribution of the two forms of monoamine oxidase within monoaminergic neurons of guinea pig brain. J. Neurochem. 48, 609–614.
Ross S.B. and Renyi A.L. (1969). Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue. Eur J. Pharmacol. 7, 270–277.
Sharman D.F. (1976). Can the intra- and extra-homoneuronal metabolism of catecholamines be distinguished in the mammalian central nervous system? Ciba Found. Symp. 39, 203–216.
Stenstrom A., Arai Y. and Oreland L. (1985). Intra - and extraneuronal monoamine oxidase -A and -B activities after central axotomy (hemitransection) on rats. J. Neural Transm. 61, 105–113.
Stenstrom A., Hardy J. and Oreland L. (1987). Intra- and extra-dopamine-synaptosomal localization of monoamine oxidase in striatal homogen-ates from four species. Submitted.
Strolin Benedetti M., Boucher T., Carlsson A. and Fowler C.J. (1983). Intestinal metabolism of tyramine by both forms of monoamine oxidase in the rat. Biochem. Pharmacol. 26, 2337–2342.
Sullivan J.P., McDonnell L., Hardiman O.M., Farrell M.A. and Tipton K.F. (1986). The oxidation of tryptamine by the two forms of monoamine oxidase in human tissues. Biochem. Pharmacol. 35, 3255–3260.
Sundstrom E. and Jonsson G. (1985). Pharmacological interference with the neurotoxic actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholaminergic neurons in the mouse. Eur. J. PHarmacol. 110, 293–299.
Thorpe L.W., Westlund K.N., Kochersperger L.M., Abell C.W. and Denney R.M. (1987). Innmunocyto-chemical localisation of monoamine oxidase A and B in human peripheral tissues and brain. J. Histochem. Cytochem. 35, 23–32.
Tipton K.F. (1986). Enzymology of monoamine oxidase. Cell Biochem. Funct. 4, 79–87.
Tipton K.F., Dostert P. and Strolin Benedetti M. (eds) (1984). Monoamine Oxidase and Disease. Academic Press, London.
Tipton K.F., McCrodden J.M. and Youdim M.B.H. (1986). Oxidation and enzyme-activated irreversible inhibition of rat liver monoamine oxidase-B by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Biochem. J. 240, 379–383.
Van der Krogt J.A., Koot-Gronsveld E. and Van den Berg C. (1983). Localisation of rat striatal monoamine oxidase activities towards dopamine, serotonin and kynuramine by gradient centrifugation and nigrostriatal lesions. Life Sci. 33, 615–623.
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Tipton, K.F. et al. (1988). Localization and Inhibition of Monoamine Oxidase. In: Boulton, A.A., Juorio, A.V., Downer, R.G.H. (eds) Trace Amines. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4602-2_29
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DOI: https://doi.org/10.1007/978-1-4612-4602-2_29
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