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Muscarinic Receptor Regulation of Cyclic GMP and Eicosanoid Production

  • Chapter
The Muscarinic Receptors

Part of the book series: The Receptors ((REC))

Overview

For many of the cells or tissues in which muscarinic receptors are located, activation of these receptors results in elevated tissue levels of cyclic guanosine 3 ′,5 ′-monophosphate (cyclic GMP). Cyclic GMP and the enzyme that synthesizes this cyclic nucleotide are widely distributed (Goldberg and Haddox, 1977), and the muscarinic receptor is one of several receptors that mediates increased intracellular levels of cyclic GMP. Of the two forms of guanylate cyclase that exist, soluble and particulate, the muscarinic receptor is thought to activate the soluble form. This activation has generally been considered an indirect effect, involving a second messenger, since muscarinic receptors cannot activate guanylate cyclase in broken cell preparations. Calcium or a metabolite of arachidonic acid are the two most likely candidates for this second messenger.

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Authors
  1. Michael McKinney
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  2. Elliott Richelson
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  1. University of California, San Diego, La Jolla, California, USA

    Joan Heller Brown

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McKinney, M., Richelson, E. (1989). Muscarinic Receptor Regulation of Cyclic GMP and Eicosanoid Production. In: Brown, J.H. (eds) The Muscarinic Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4498-1_8

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  • DOI: https://doi.org/10.1007/978-1-4612-4498-1_8

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