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Retinoids: Concepts for Separation of Desirable and Undesirable Effects in the Treatment or Prevention of Cancer

  • Chapter
Hormones and Cancer

Part of the book series: Hormones in Health and Disease ((HHD))

Abstract

Since its discovery early this century, vitamin A has been known to play essential biological roles (Lotan, 1981; Roberts and Sporn, 1984; Morris-Kay 1992). It has now been established that the active derivatives of vitamin A such as all-trans retinoic acid (ATRA) and 9-cis retinoic acid (9-cis RA) as well as their synthetic analogs—the retinoids—function as hormone-like signaling molecules that affect important biological processes at the level of gene transcription. The ability of retinoids to regulate growth and development, cell proliferation, and differentiation made them particularly attractive as therapeutic candidates for the treatment of cancer and other proliferative diseases. In fact, 13-cis RA and related retinoids are the most effective drugs known today for the treatment of acne vulgaris and other skin diseases (reviewed in Schaefer and Reichert, 1990). In addition, ATRA has recently been approved for the treatment of acute promyelocytic leukemia (APL) where it leads to complete remission (Huang et al., 1988; Castaigne et al., 1990; Chen et al., 1991). Retinoids have also shown promise for the treatment and prevention of many other cancers including cancers of the head and neck, cervical cancer, and most other epithelial tissue-derived cancers (reviewed in Bollag and Holdener, 1992; Smith et al., 1992; Meyskens et al., 1994).

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  1. Magnus Pfahl
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  1. Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, 1901 Perdido Street, 70112-1393, New Orleans, LA, USA

    Wayne V. Vedeckis

  2. Stanley S. Scott Cancer Center, 1901 Perdido Street, 70112-1393, New Orleans, LA, USA

    Wayne V. Vedeckis

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Pfahl, M. (1996). Retinoids: Concepts for Separation of Desirable and Undesirable Effects in the Treatment or Prevention of Cancer. In: Vedeckis, W.V. (eds) Hormones and Cancer. Hormones in Health and Disease. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4266-6_5

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