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Multifactor Interaction Network of Carcinogenesis — A “Tour Guide”

  • Chapter
Chemical Induction of Cancer

Abstract

Many exogenous and endogenous factors influence or in some instances can actually determine the outcome of the administration of a chemical carcinogen. The multiplicity of these factors outdates the classical concept that a given carcinogen is the sole etiological agent in the “causation of a cancer”, except when under controlled laboratory conditions or resulting from well-defined occupational or lifestyle exposures. In the same framework the significance of the search for “threshold” of carcinogens acquires an illusory character unless nutritional, genetic, lifestyle, and stress factors, and exposure to radiations, viruses, and a host of environmentally occurring chemicals—such as immunotoxicants, modifiers of mixed-function oxidases (MFO) and of endocrine balance, and antagonists and/or synergists-are taken into account (cf. 1). In addition, the majority of the factors that can modulate carcinogenesis directly and indirectly (Table 1) influence the effect of each other, so that the totality forms a complex, interwoven interaction network.

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Authors
  1. Joseph C. Arcos
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  2. Mary F. Argus
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Editors and Affiliations

  1. U.S. Environmental Protection Agency, Washington, D.C., 20460, USA

    Joseph C. Arcos , Mary F. Argus  & Yin-tak Woo ,  & 

  2. Tulane University School of Medicine, New Orleans, LA, 70112, USA

    Joseph C. Arcos  & Mary F. Argus  & 

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Arcos, J.C., Argus, M.F. (1995). Multifactor Interaction Network of Carcinogenesis — A “Tour Guide”. In: Arcos, J.C., Argus, M.F., Woo, Yt. (eds) Chemical Induction of Cancer. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4076-1_1

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  • DOI: https://doi.org/10.1007/978-1-4612-4076-1_1

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