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Prostate Cancer

  • Chapter
Human Cytogenetic Cancer Markers

Part of the book series: Contemporary Biomedicine ((CB,volume 13))

Abstract

As the leading malignancy of males in Western countries, prostate cancer has become a major research focus, yet only recently have techniques become available for the accurate study of this complex tumor. Clinically, prostate tumors follow widely varying courses of progression, with a subset of tumors showing little or no advancement and rarely causing death, in contrast to aggressive tumors that metastasize to bone, lymph nodes or other sites and kill the patient. There is currently no biological marker that can distinguish the indolent from the aggressive form of this disease. Current methods for prostate cancer detection include digital rectal examination, ultrasonic analysis, and assay for serum levels of the prostatic specific antigen (PSA). Although PSA screening, combined with digital rectal examination is the most sensitive test to date, it fails to detect all tumors, gives false positive results, and cannot distinguish indolent from aggressive tumors. Treatment of early-stage prostate cancer in the United States often involves removal of the prostate gland, especially in otherwise healthy men, but the surgery is often complicated by significant side effects, including incontinence and impotence which negatively affect the quality of postsurgical life.

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Authors
  1. Arthur R. Brothman
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  2. Briana J. Williams
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Editors and Affiliations

  1. Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    Sandra R. Wolman MD

  2. Department of Pathology, Albany Medical College, Albany, NY, USA

    Stewart Sell MD

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© 1997 Humana Press Inc.

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Brothman, A.R., Williams, B.J. (1997). Prostate Cancer. In: Wolman, S.R., Sell, S. (eds) Human Cytogenetic Cancer Markers. Contemporary Biomedicine, vol 13. Humana Press. https://doi.org/10.1007/978-1-4612-3952-9_10

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  • DOI: https://doi.org/10.1007/978-1-4612-3952-9_10

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8437-6

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