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Birth Control Vaccines Inducing Antibodies Against Chorionic Gonadotropin

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Contraception Research for Today and the Nineties

Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 1))

Abstract

The possibility of inducing antibodies against reproductive tract antigens by deliberate immunization was indicated as early as 1899 by the pioneering work of Landsteiner (14) and Metchinikoff (15). These leaders of immunology did obtain antisera toxic to sperm. However, the practical utility of this lead for control of fertility could not materialize owing to several factors. Crude tissue extracts induced antibodies reactive to unwanted tissues with potential toxicity hazards. Not enough was known of the immune processes and the manner in which these could be modulated to advantage. Furthermore, for antigens localized on sperm, it would be necessary to ensure the right type of immune reactions in the genital tract for preventing fertilization; antibodies in systemic circulation alone may not suffice.

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Authors
  1. G. P. Talwar
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  2. Om Singh
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Editor information

Editors and Affiliations

  1. National Institute of Immunology, JNU Complex, Shahid Jeet Singh Marg, 110 067, New Delhi, India

    G. P. Talwar

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© 1988 Springer-Verlag New York Inc.

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Talwar, G.P., Singh, O. (1988). Birth Control Vaccines Inducing Antibodies Against Chorionic Gonadotropin. In: Talwar, G.P. (eds) Contraception Research for Today and the Nineties. Progress in Vaccinology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3746-4_17

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  • DOI: https://doi.org/10.1007/978-1-4612-3746-4_17

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8331-7

  • Online ISBN: 978-1-4612-3746-4

  • eBook Packages: Springer Book Archive

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