Abstract
Ivermectin is used widely as an antiparasitic agent in food-producing animals. As in the case of any such drug, the residual tissue concentration of the therapeutic agent, or tissue residue, is a safety concern to the meat-consuming public. To evaluate the toxic potential of the residual tissue concentration of ivermectin and its metabolites, metabolism studies have been carried out in target species (cattle, sheep, swine) using the radiolabeled drug. Comparative metabolic studies were done in a laboratory animal, the rat, and in liver microsomes from various species.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Caldwell J, Marsh MV (1983) Interrelationships between xenobiotic metabolism and lipid biosynthesis. Biochem. Pharm. 32:1667–1672
Campbell WC, Fisher MH, Stapley EO, Albers-Schonber G, Jacob TA (1983) Ivermectin: A potent new antiparasitic agent. Science 221:923–928
Chiu SHL, Buhs RP, Sestokas E, Taub R, Jacob TA (1985) Determination of ivermectin residue in animal tissues by high performance liquid chroma- tography-reverse isotope dilution assay. J. Agric. Food Chem. 33:99–102
Chiu SHL, Carlin JR, Taub R, Sestokas E, Zweig J, VandenHeuval WJA, Jacob TA (1988) Comparative metabolic disposition of ivermectin in fat tissues of cattle, sheep, and rats. Drug Me tab. & Dispos. 16:728–736
Chiu SHL, Sestokas E, Taub R, Buhs RP, Green M, Sestokas R, VandenHeuvel WJA, Arison BH, Jacob TA (1986) Metabolic disposition of ivermectin in tissues of steers, sheep, and rats. Drug Metab. & Dispos. 14:590–600
Chiu SHL, Sestokas E, Taub R, Smith JL, Arison B, Lu AYH (1984) The metabolism of avermectin-H2B1a and -H2B1b by pig liver microsomes. Drug Metab. & Dispos. 12:464–469
Chiu SHL, Taub R, Sestokas E, Lu AYH, Jacob TA (1987) Comparative in vivo and in vitro metabolism of ivermectin in steers, sheep, swine, and rat. Drug Metab. Rev. 18:289–302
Dell HD, Fiedler J, Kamp R, Gaug W, Kurz J, Weber B, Wuensche C (1982) Etofenamate fatty acid esters, an example of a new route of drug metabolism. Drug Metab. & Dispos. 10:55–60
Dorough HW (1980) Classification of radioactive pesticide residues in food- producing animals. J. Environ. Path. Toxicol. 3:11–19
Jacob TA, Buhs RP, Carlin JR, Chiu SHL, Miwa GT, Rosegay A (1983) The metabolism and tissue residue profiles of ivermectin. In Proceedings of the MSD AGVET Symposium on Recent Developments in the Control of Animal Parasites, XXII World Veterinary Congress, Perth, Australia
Leighty EG, Fentiman Jr AF, Foltz RL (1976) Long-chain metabolites of Δ9- and Δ8-tetrahydrocannabinols identified as novel fatty acid conjugates. Res. Comm. Chem. Pathol. Pharm. 14:13–28
Lu AYH, Wislocki PG, Chiu SHL, Miwa GT (1987) Tissue drug residues and their toxicological significance. Drug Metab. Reviews 18:363–378
Miwa GT, Walsh JS, VandenHeuvel WJA, Arison B, Sestokas E, Buhs R, Rosegay A, Avermitilis S, Lu AYH, Walsh MAR, Walker RW, Taub R, Jacob TA (1982) The metabolism of avermectins B1a, H2B1a and H2B1b by liver microsomes. Drug Metab. & Dispos. 10:268–274
Pivnichny JV, Shim J-SK, Zimmerman LA (1983) Direct determination of avermectins in plasma at nanogram levels by high-performance liquid chromatography. J. Pharm. Sci. 72:1447–1450
Schmid J, Prox A, Baeur E, Koss FW (1980) Abstract No. 434, 7th European Workshop on Drug Metabolism, Zurich
Stong JD (1987) Determination of ivermectin by fluorescence derivatization. Anal. Chem. 59:266–270
Tolan JW, Eskola P, Fink DW, Mrozik H, Zimmerman LA (1980) Determination of avermectin in plasma at nanogram levels using high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 190:367–376
Tway PC, Wood Jr JS, Downing GV (1981) Determination of ivermectin in steers and sheep tissues using high-performance liquid chromatography with fluorescence detection. J. Agric. Food Chem. 29:1059–1063
Weber NE (1980) Persistent residues: Interface with regulatory decisions. J. Environ. Path. Toxicol. 3:35–43
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Chiu, SH.L., Lu, A.Y.H. (1989). Metabolism and Tissue Residues. In: Campbell, W.C. (eds) Ivermectin and Abamectin. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3626-9_8
Download citation
DOI: https://doi.org/10.1007/978-1-4612-3626-9_8
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-8184-9
Online ISBN: 978-1-4612-3626-9
eBook Packages: Springer Book Archive