Abstract
Several peptides of the tachykinin family, substance P (SP), neurokinin A (NKA), and neuropeptide K are present in subpopulations of primary afferent neurons. SP-like immunoreactive (SP-LI) nerve fibers have been observed in the carotid body of many species (1–5) and it has been hypothesized that these axons represent the chemoreceptor afferents (4). This interpretation, however, generally, is not accepted (5), and, in fact, even the exact origin of SP-LI nerve fibres innervating the carotid body is unknown. Degeneration experiments revealed that, in the guinea pig, the bulk of SP-LI fibers is supplied via the carotid sinus nerve (CSN) to the carotid body (3). Extending this investigation, the present study was aimed to determine origin, ultrastructure, and coexisting peptides of these fibers.
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References
Lundberg JM, Hökfelt T, Fahrenkrug J, Nilsson G, Terenius L (1979). Peptides in the cat carotid body (glomus caroticum): VIP-, enkephalin-, and substance P-like immunoreactivity. Acta Physiol Scand 107: 279–281.
Chen I-L, Yates RD, Hansen JT (1986). Substance P-like immunoreactivity in rat and cat carotid bodies: Light and electron microscopic studies. Histol Histopath 1: 203–212.
Kummer W (1987). Calcitonin gene-related peptide-immunoreactive nerve fibers in carotid body and carotid sinus. In: Heym C (Ed). Histochemistry and Cell Biology of Autonomic Neurons and Paraganglia, Berlin: Springer Verlag, pp 84–88. (Experimental Brain Research Series 16 ).
Helke CJ, O’Donohue TJ, Jacobowitz DM (1980). Substance P as a baro- and chemoreceptor afferent neurotransmitter: immunocytochemical and neuro-chemical evidence in the rat. Peptides 1: 1–9.
Yates RD, Chen I (1987). Substance P in the carotid body. In: Heym C (Ed). Histochemistry and Cell Biology of Autonomic Neurons and Paraganglia, Berlin: Springer Verlag, pp 78–83. (Experimental Brain Research Series 16 ).
Bendayan M (1982). Double immunocytochemical labelling applying the protein A-gold technique. J Histochem Cytochem 30: 81–85.
Kummer W (1988). Retrograde neuronal labelling and double-staining immunohistochemistry of tachykinin-and calcitonin gene-related peptide immunoreactive pathways in the carotid sinus nerve of the guinea pig. J Autonomic Nery Syst 23: 131–141.
Gulbenkian S, Merighi A, Wharton J, Varndell IM, Polak JM (1986). Ultra-structural evidence for the coexistence of calcitonin gene-related peptide and substance P in secretory vesicles of peripheral nerves in the guinea pig. J Neurocytol 15: 535–542.
McQueen DS (1980). Effects of substance P on carotid chemoreceptor activity in the cat. J Physiol (Lond) 302: 31–47.
Prabhakar NR, Runold M, Yamamoto Y, Lagercrantz H, von Euler C (1984). Effect of substance P antagonist on the hypoxia induced carotid chemoreceptor activity. Acta Physiol Scand 121: 301–303.
Gamse R, Saria A (1985). Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide. Europ J Pharmacol 114: 61–66.
Martling C-R, Saria A, Fischer JA, Hökfelt T, Lundberg JM (1988). Calcitonin gene-related peptide and the lung: neuronal coexistence with substance P, release by capsaicin and vasodilatory effect. Regul Peptides 20: 125–139.
Fidone SJ, Sato A (1969). A study of chemoreceptor and baroreceptor A- and C-fibers in the cat carotid nerve. J Physiol (Lond) 205: 527–548.
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Kummer, W., Fischer, A. (1990). Tachykininergic Axons in the Guinea Pig Carotid Body: Origin, Ultrastructure, and Coexistence with Other Peptides. In: Eyzaguirre, C., Fidone, S.J., Fitzgerald, R.S., Lahiri, S., McDonald, D.M. (eds) Arterial Chemoreception. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3388-6_31
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DOI: https://doi.org/10.1007/978-1-4612-3388-6_31
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