Skip to main content

Plaque Hemorrhages, Their Genesis and Their Role in Supra-Plaque Thrombosis and Atherogenesis

  • Conference paper
Pathobiology of the Human Atherosclerotic Plaque

Abstract

The last and most lethal step in the evolution of advanced atherosclerosis in coronary arteries is thrombosis in diseased vessels — something that practically never occurs in normal arteries.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Paterson JC (1938) Capillary rupture with intimal hemorrhage as a causative factor in coronary thrombosis. AMA Arch Pathol 25:474–479.

    Google Scholar 

  2. Constantinides P (1965) Experimental Atherosclerosis. Amsterdam: Elsevier Publishers, pp. 27–34, 41.

    Google Scholar 

  3. Constantinides P (1965) Experimental Atherosclerosis. Amsterdam: Elsevier Publishers, pp. 34–39.

    Google Scholar 

  4. Constantinides P, Robinson M (1969) Ultrastructural injury of arterial endothelium. III. Effects of enzymes and surfactants. Arch Pathol 88:113–117.

    PubMed  CAS  Google Scholar 

  5. Constantinides P (1964) Plaque fissures in human coronary thrombosis. Fed Proc 23:443.

    Google Scholar 

  6. Constantinides P (1964) Plaque fissures in human coronary thrombosis. JAMA 188(6):35–37 (Medical News Section).

    Google Scholar 

  7. Constantinides P (1966) Plaque fissures in human coronary thrombosis. J Atheroscler Res 6:1–17.

    Article  Google Scholar 

  8. Constantinides P (1967) Pathogenesis of cerebral artery thrombosis in man. Arch Pathol 83:422–428.

    PubMed  CAS  Google Scholar 

  9. Chapman I (1965) Morphogenesis of occluding coronary artery thrombosis. Arch Pathol 80:256–261.

    PubMed  CAS  Google Scholar 

  10. Sinapius D (1965) Uber Wandveranderungen bei Coronar-thrombose. Klin Wschr 43:875–880.

    Article  PubMed  CAS  Google Scholar 

  11. Friedman M, Bovenkamp GI (1966) The pathogenesis of a coronary thrombus. Am J Pathol 48:19–39.

    PubMed  CAS  Google Scholar 

  12. Davies MJ, Thomas A (1981) The pathological basis and microanatomy of occlusive thrombus formation in human coronary arteries. Philos Trans R Soc London (Biol) 294:225–229.

    Article  CAS  Google Scholar 

  13. Davies MJ, Thomas A (1984) Thrombosis and acute coronary artery lesions in sudden cardiac ischemic death. N Engl J Med 310:1137–1140.

    Article  PubMed  CAS  Google Scholar 

  14. Falk E (1983) Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Brit Heart J 50:127–134.

    Article  PubMed  CAS  Google Scholar 

  15. Rokitansky C (1852) A Manual of Pathologic Anatomy. London: The Sydenham Society.

    Google Scholar 

  16. Duguid JB (1948) Thrombosis as a factor in the pathogenesis of aortic atherosclerosis. J Pathol Bact 60: 57–69.

    Article  CAS  Google Scholar 

  17. Morgan AD (1956) The Pathogenesis of Coronary Occlusion. Springfield, IL: CC Thomas.

    Google Scholar 

  18. Constantinides P (1984) Atherosclerosis — A general survey and synthesis. Surv Synth Pathol Res 3:477–498.

    PubMed  CAS  Google Scholar 

  19. Lusby RJ, Woodcock JP, Machleder HI, et al. (1982) Transient ischaemic attacks: The static and dynamic morphology of the carotid artery bifurcation. Brit J Surg 69 (Suppl):S41-S44.

    Article  PubMed  Google Scholar 

  20. Constantinides P (1984) Ultrastructural Pathobiology. Amsterdam: Elsevier Publishers, pp. 78–150.

    Google Scholar 

  21. Constantinides P, Wiggers KD (1974) Electron microscopic autoradiographic study of cholesterol passage across arterial and capillary endothelium. Virch Arch A Pathol Anat Histol 326:291–310.

    Article  Google Scholar 

  22. Anitschkow N (1933) In: Cowdry EV (ed) Arteriosclerosis — A Survey of the Problem. New York: MacMillan, Chapter 10.

    Google Scholar 

  23. Adams CW (1971) Lipids, lipoproteins and atherosclerosis. Proc Roy Soc Med 64:902.

    PubMed  CAS  Google Scholar 

  24. Benditt EP, Benditt JM (1973) Evidence for a monoclonal origin of human atherosclerotic plaque. Proc Natl Acad Sci USA 70:1753–1756.

    Article  PubMed  CAS  Google Scholar 

  25. Barger AC, Beeuwkes R III, Lainey LL, Silverman KJ (1984) Hypothesis: Vasa vasorum and neovascularization of human coronaries. A possible role in the pathophysiology of atherosclerosis. N Engl J Med 310:175–177.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag New York Inc.

About this paper

Cite this paper

Constantinides, P. (1990). Plaque Hemorrhages, Their Genesis and Their Role in Supra-Plaque Thrombosis and Atherogenesis. In: Glagov, S., Newman, W.P., Schaffer, S.A. (eds) Pathobiology of the Human Atherosclerotic Plaque. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3326-8_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-3326-8_26

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7968-6

  • Online ISBN: 978-1-4612-3326-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics