Abstract
The discovery in 1981 of the spirochete, now known as Borrelia burgdorferi, as the etiological agent of Lyme disease in the United States and of associated clinical manifestations in Europe (11, 12) has rekindled interest in arthropod-borne spirochetoses. Since then, hundreds of publications have appeared that deal not only with the complex clinical aspects of Lyme disease but also with the natural history of this agent, and particularly its relationship to its arthropod vector—sticks of the genus Ixodes. In the United States, where Lyme disease is now considered the most prevalent tick-borne disease (16), B. burgdorferi is associated with at least three Ixodes species, namely Ixodes dammini in the northeastern and midwestern regions of the country, Ixodes pacificus in the West, and possibly Ixodes scapularis in the Southeast. In Europe (55), the sheep or castor bean tick, Ixodes ricinus, is the vector, whereas in Asia Ixodes persulcatus is said (17) to be involved in the maintenance and distribution of the Lyme disease spirochete.
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Burgdorfer, W., Hayes, S.F. (1989). Vector—Spirochete Relationships in Louse-Borne and Tick-Borne Borrelioses with Emphasis on Lyme Disease. In: Harris, K.F. (eds) Advances in Disease Vector Research. Advances in Disease Vector Research, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3292-6_5
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