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The Multifunctional Nature of Peptide Growth Factors

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Peptide Growth Factors and Their Receptors I

Part of the book series: Springer Study Edition ((SSE))

Abstract

It might seem paradoxical, perhaps even capricious and quixotic, to introduce this first comprehensive treatise on peptide growth factors with a statement that in reality there is no such thing as a peptide growth factor. Indeed, this treatise does concern itself with an extremely potent set of regulators of cell growth, all of which are peptides, many newly discovered. However, at the beginning of these two volumes, it is important to emphasize that all the peptides considered here actually are elements of a complex biological signaling language, providing the basis for intercellular communication in multicellular organisms. Thus, the “peptide growth factors” that are the topic of this treatise in reality are peptide signaling molecules. They often promote cell growth, but they also can inhibit it; moreover, they regulate many other critical cellular functions, such as control of differentiation and many other processes that have little to do with growth itself. Like the symbols or alphabet of a language or code, the meaning of the action of these peptide signaling molecules can only be understood in context with other symbols. Thus, all peptide growth factors act in sets, and to understand their actions, one must always consider the biological context in which they act.

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References

  • Angel P, Hattori K, Smeal T, Karin M (1988) The jun proto-oncogene is positively autoregulated by its product, jun/AP-1. Cell 55:875–885.

    Article  PubMed  CAS  Google Scholar 

  • Angeletti RH, Bradshaw RA (1971) Nerve growth factor from mouse submaxillary glands: amino acid sequence. Proc Natl Acad Sci USA 68:2417–240.

    Article  PubMed  CAS  Google Scholar 

  • Ayer-LeLievre CS, Olson L, Ebendal T, Hallböök F, Persson H (1988) Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat. Proc Natl Acad Sci USA 85:2628–2632.

    Article  PubMed  CAS  Google Scholar 

  • Barkai A, McQuaid C (1988) Predator-prey role reversal in a marine benthic ecosystem. Science 242:62–64.

    Article  PubMed  CAS  Google Scholar 

  • Bissell MJ, Hall G, Parry G (1982) How does the extracellular matrix direct gene expression? J Theor Biol 99:31–68.

    Article  PubMed  CAS  Google Scholar 

  • Bothwell M, Patterson SL, Schatteman GC, Thompson S, Underwood R, Claude P, Holbrook K, Byers M, Gown AM (1989) Regulated expression of nerve growth factor receptors in mesenchymal cells. Submitted Buck CA, Horwitz AF (1987) Cell surface receptors for extracellular matrix molecules. Annu Rev Cell Biol 3:179–205.

    Article  Google Scholar 

  • Buck CA, Horwitz AF (1987) Cell Surface receptors for extracellular matrix molecules. Annu Rev Cell Biol 3:179–205.

    Article  PubMed  CAS  Google Scholar 

  • Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M (1988) The c-fos protein interacts with c-jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54:541–552.

    Article  PubMed  CAS  Google Scholar 

  • Coffey RJ Jr, Derynck R, Wilcox JN, Bringman TS, Goustin AS, Moses HL, Pittelkow MR (1987) Production and auto-induction of transforming growth factor-α in human keratinocytes. Nature 328:817–820.

    Article  PubMed  CAS  Google Scholar 

  • Cohen S (1960) Purification of a nerve-growth promoting protein from the mouse salivary gland and its neurotoxic antiserum. Proc Natl Acad Sci USA 46:302–311.

    Article  PubMed  CAS  Google Scholar 

  • Cohen S (1962) Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal. J Biol Chem 237:1555–1562.

    PubMed  CAS  Google Scholar 

  • Curran T, Franza BR (1988) Fos and jun: the AP-1 connection. Cell 55:395–397.

    Article  PubMed  CAS  Google Scholar 

  • Edelmann GM (1988) Topobiology: an introduction to molecular embryology. Basic Books, New York.

    Google Scholar 

  • Ernfors P, Hallböök F, Ebendal T, Shooter EM, Radeke MJ, Misko TP, Persson H (1988) Developmental and regional expression of ß-nerve growth factor receptor mRNA in the chick and rat. Neuron 1:983–996.

    Article  PubMed  CAS  Google Scholar 

  • Espevik T, Figari IS, Ranges GE, Palladino MA (1988) Transforming growth factor-ß and recombinant human tumor necrosis factor-a reciprocally regulate the generation of lymphokine-activated killer cell activity. J Immunol 140:2312–2316.

    PubMed  CAS  Google Scholar 

  • Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889–895.

    Article  PubMed  CAS  Google Scholar 

  • Folkman J, Klagsbrun M (1987) Angiogenesis factors. Science 235:442–447.

    Article  PubMed  CAS  Google Scholar 

  • Gan BS, Hollenberg MD, MacCannell KL, Lederis K, Winkler ME, Derynck R (1987) Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha. J Pharmacol Exp Ther 242:331–337.

    PubMed  CAS  Google Scholar 

  • Green S, Chambon P (1986) A superfamily of potentially oncogenic hormone receptors. Nature 324:615–617.

    Article  PubMed  CAS  Google Scholar 

  • Gregory H, Wiltshire IR (1975) The isolation of the urogastrones — inhibitors of gastric acid secretion — from human urine. Hoppe-Seylers Z Physiol Chem 356:1765–1774.

    Article  PubMed  CAS  Google Scholar 

  • Harrison LC, Campbell IL (1988) Cytokines: an expanding network of immuno-inflammatory hormones. Mol Endocrinol 2:1151–1156.

    Article  PubMed  CAS  Google Scholar 

  • Hatakeyama M, Minamoto S, Uchiyama T, Hardy RR, Yamada G, Taniguchi T (1985) Reconstitution of functional receptor for human interleukin-2 in mouse cells. Nature 318:467–470.

    Article  PubMed  CAS  Google Scholar 

  • Heldin C-H, Westermark B (1984) Growth factors: mechanism of action and relation to oncogenes. Cell 37:9–20.

    Article  PubMed  CAS  Google Scholar 

  • Hill DL, Strain A J, Elstow SF, Swenne I, Milner RDG (1986) Bi-functional action of transforming growth factor-ß on DNA synthesis in early passage human fetal fibroblasts. J Cell Physiol 128:322–328.

    Article  PubMed  CAS  Google Scholar 

  • Hynes RO (1987) Integrins: a family of cell surface receptors. Cell 48:549–554.

    Article  PubMed  CAS  Google Scholar 

  • Izumo S, Nadal-Ginard B, Mahdavi V (1986) All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner. Science 231:597–600.

    Article  PubMed  CAS  Google Scholar 

  • Kehrl JH, Roberts AB, Wakefield LM, Jakowlew S, Sporn MB, Fauci AS (1986 a) Transforming growth factor-beta is an important immunomodulatory protein for human B lymphocytes. J Immunol 137:3855–3860.

    PubMed  CAS  Google Scholar 

  • Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS (1986 b) Production of transforming growth factor-beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 163:1037–1050.

    Article  PubMed  CAS  Google Scholar 

  • Kishimoto T, Hirano T (1988) Molecular regulation of B lymphocyte response. Annu Rev Immunol 6:485–512.

    Article  PubMed  CAS  Google Scholar 

  • Komm BS, Terpening CM, Ben DJ, Graeme KA, Gallegos A, Korc M, Greene GL, O’Malley BW, Haussler MR (1988) Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science 241:81–86.

    Article  PubMed  CAS  Google Scholar 

  • Kouzarides T, Ziff E (1988) The role of the leucine zipper in the fos-jun interaction. Nature 336:646–651.

    Article  PubMed  CAS  Google Scholar 

  • Kumar V, Chambon P (1988) The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 55:145–156.

    Article  PubMed  CAS  Google Scholar 

  • Landschulz WH, Johnson PF, McKnight SL (1988) The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240:1759–1764.

    Article  PubMed  CAS  Google Scholar 

  • Le J, Vilcek J (1987) Biology of disease: tumor necrosis factor and interleukin 1: Cytokines with multiple overlapping biological activities. Lab Invest 56:234–248.

    PubMed  CAS  Google Scholar 

  • Levi-Montalcini R, Hamburger V (1953) A diffusable agent of mouse sarcoma producing hyperplasia of sympathetic ganglia and hyperneurotization of viscera in the chick embryo. J Exp Zool 123:233–288.

    Article  Google Scholar 

  • Matsuda H, Coughlin MD, Bienenstock J, Denburg JA (1988) Nerve growth factor promotes human hemopoietic colony growth and differentiation. Proc Natl Acad Sei USA 85:6508–6512.

    Article  CAS  Google Scholar 

  • Mercola M, Stiles CD (1988) Growth factor superfamilies and mammalian embryogenesis. Development 102:451–460 Minghetti PP, Norman AW (1988) 1,25 (OH)2-Vitamin D3 receptors: gene regulation and genetic circuitry. FASEB J 2:3043–3053.

    Google Scholar 

  • Minghetti PP, Norman AW (1988)Growth factor superfamilies and mammalian embryogenesis. Development 102: 451–460

    Google Scholar 

  • Nimer SD, Champlin RE, Golde DW (1988) Serum cholesterol-lowering activity of granulocyte-macrophage colony-stimulating factor. JAMA 260:3297–3300.

    Article  PubMed  CAS  Google Scholar 

  • Panaretto BA, Leish Z, Moore GPM, Robertson DM (1984) Inhibition of DNA synthesis in dermal tissue of Merino sheep treated with depilatory doses of mouse epidermal growth factor. J Endocrinol 100:25–31.

    Article  PubMed  CAS  Google Scholar 

  • Paulsson Y, Hammacher A, Heldin C-H, Westermark B (1987) Possible positive autocrine feedback in the prereplicative phase of human fibroblasts. Nature 328:715–717.

    Article  PubMed  CAS  Google Scholar 

  • Petkovich M, Brand NJ, Krust A, Chambon P (1987) A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330:444–450.

    Article  PubMed  CAS  Google Scholar 

  • Rauscher FJ III, Cohen DR, Curran T, Bos TJ, Vogt PK, Bohmann D, Tjian R, Franza BR Jr (1988) Fas-associated protein p39 is the product of the jun proto- oncogene. Science 240:1010–1016.

    Article  PubMed  CAS  Google Scholar 

  • Rennick D, Yang G, Muller-Sieburg C, Smith C, Arai N, Takabe Y, Gemmel L (1987) Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor- dependent growth of hemopoietic progenitor cells. Proc Natl Acad Sei USA 86:6889–6893.

    Article  Google Scholar 

  • Rhodes JA, Fitzgibbon DH, Macchiarulo PA, Murphy RA (1987) Epidermal growth factor-induced precocious incisor eruption is associated with decreased tooth size. Dev Biol 121:247–252.

    Article  PubMed  CAS  Google Scholar 

  • Roberts AB, Anzano MA, Wakefield LM, Roche NS, Stern DF, Sporn MB (1985) Type ß transforming growth factor: a Afunctional regulator of cellular growth. Proc Natl Acad Sei USA 82:119–123.

    Article  CAS  Google Scholar 

  • Rosen DM, Stempien SA, Thompson AY, Seyedin SM (1988) Transforming growth factor-ß modulates the expression of osteoblast and chondroblast phenotypes in vitro. J Cell Physiol 134:337–346.

    Article  PubMed  CAS  Google Scholar 

  • Ruoslahti E, Pierschbacher MD (1987) New perspectives in cell adhesion. Science 238:491–497.

    Article  PubMed  CAS  Google Scholar 

  • Santoro C, Mermod N, Andrews PC, Tjian R (1988) A family of human CCAAT-box binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature 334:218–224.

    Article  PubMed  CAS  Google Scholar 

  • Sassone-Corsi P, Ransone LJ, Lamph WW, Verma IM (1988 a) Direct interaction between fos and jun nuclear oncoproteins: role of the leucine zipper domain. Nature 336:692–694.

    Article  PubMed  CAS  Google Scholar 

  • Sassone-Corsi P, Sisson JC, Verma IM (1988 b) Transcriptional autoregulation of the proto-oncogene fos. Nature 334:314–319.

    Article  PubMed  CAS  Google Scholar 

  • Schlessinger J (1988) Signal transduction by allosteric receptor oligomerization. Trends Biochem Sei 13:443–147.

    Article  CAS  Google Scholar 

  • Sehgal PB, May LT, Tamm I, Vilcek J (1987) Human ß2 interferon and B-cell differentiation factor BSF-2 are identical. Science 235:731–732.

    Article  PubMed  CAS  Google Scholar 

  • Seyedin SM, Segarini PR, Rosen DM, Thompson AY, Bentz H, Graycar J (1987) Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-ß. J Biol Chem 262:1946–1949.

    PubMed  CAS  Google Scholar 

  • Short NJ (1988) Regulation of transcription: flexible interpretation. Nature 334:192–193.

    Article  PubMed  CAS  Google Scholar 

  • Sporn MB, Roberts AB (1986) Peptide growth factors and inflammation, tissue repair and cancer. J Clin Invest 78:329–332.

    Article  PubMed  CAS  Google Scholar 

  • Sporn MB, Roberts AB (1988) Peptide growth factors are multifunctional. Nature 332:217–219.

    Article  PubMed  CAS  Google Scholar 

  • Sporn MB, Todaro GJ (1980) Autocrine secretion and malignant transformation of cells. N Engl J Med 303:878–880.

    Article  PubMed  CAS  Google Scholar 

  • Takeichi M (1988) The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development 102:639–655.

    PubMed  CAS  Google Scholar 

  • Van Obberghen-Schilling E, Roche NS, Flanders KC, Sporn MB, Roberts AB (1988) Transforming growth factor ß1 positively regulates its own expression in normal and transformed cells. J Biol Chem 263:7741–7746.

    PubMed  Google Scholar 

  • Verma I, Sassone-Corsi P (1987) Proto-oncogene fos: complex but versatile regulation. Cell 51:513–514.

    Article  PubMed  CAS  Google Scholar 

  • Weigent DA, Blalock JE (1987) Interactions between the neuroendocrine and immune systems: common hormones and receptors. Immunol Rev 100:79–108.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. M. B. Sporn
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  2. A. B. Roberts
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Editor information

Editors and Affiliations

  1. Laboratory of Chemoprevention, National Cancer Institute, 20892, Bethesda, MD, USA

    Michael B. Sporn M.D.  & Anita B. Roberts Ph.D.  & 

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© 1991 Springer-Verlag New York Inc.

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Sporn, M.B., Roberts, A.B. (1991). The Multifunctional Nature of Peptide Growth Factors. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Springer Study Edition. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3210-0_1

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  • DOI: https://doi.org/10.1007/978-1-4612-3210-0_1

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-97729-4

  • Online ISBN: 978-1-4612-3210-0

  • eBook Packages: Springer Book Archive

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