Abstract
In 1984 the National Eye Institute received a request for a funding grant for a Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP),1 a proposal that had been 2 years in the making. Before discussing the study’s results, it is appropriate to comment on the methods used to resolve clinical management controversies, borrowing from Silverman.2
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References
Multicenter Trial of Cryotherapy for Retinopathy of Prematurity Cooperative Group. Manual of Procedures. NTIS Accession No. PB 88–163530. Springfield, VA: National Technical Information Service, U.S. Department of Commerce.
Silverman WA. Human Experimentation: A Guided Step into the Unknown. Oxford: Oxford University Press, 1985: 1–85.
Palmer EA. Results of U.S. randomized clinical trial of cryotherapy for ROP (CRYO-ROP). Doc Ophthalmol 1990; 74: 245–251.
Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity: preliminary results. Arch Ophthalmol 1988; 106: 471–479;
Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity: preliminary results. Pediatrics 1988; 81: 697–706.
Palmer EA, Flynn JT, Hardy RJ, et al. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Incidence and early course of retinopathy of prematurity. Ophthalmology 1991; 98: 1628–1640.
Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity: outcome results at three months. Arch Ophthalmol 1990; 108: 195–204.
Watzke RC, Robertson J, Palmer EA, et al. Photographic grading in the retinopathy of prematurity cryotherapy trial. Arch Ophthalmol 1990; 108: 950–955.
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© 1992 Springer-Verlag New York Inc.
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Palmer, E.A. (1992). Cryotherapy for Treatment of Threshold Retinopathy of Prematurity. In: Flynn, J.T., Tasman, W. (eds) Retinopathy of Prematurity. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2808-0_6
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DOI: https://doi.org/10.1007/978-1-4612-2808-0_6
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