Abstract
The use of PFCs in medicine has been the subject of much research over the past 30 years. Recent technological progress in second generation oxygen transport products has solved many of the problems of Fluosol DA® including PFC concentration, elimination of surfactant side effects and improved storage stability. Some side effects, most notably, thrombocytopenia and flu-like symptoms still remain to be solved. Two new oxygen transport formulations, Oxyfluor™ and Oxygent™ are in clinical trials at this time. Several applications of PFCs have been approved for use by the FDA but have languished in the market place. Prominent among these is the application of Fluosol DA® to PTCA and Imagent GI for MRI contrast in the bowel. Other applications such as cancer therapy, ultrasound contrast and direct19FMR imaging continue to show promise.
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Kaufman, R.J. (1995). Clinical Development of Perfluorocarbon-based Emulsions as Red Cell Substitutes. In: Winslow, R.M., Vandegriff, K.D., Intaglietta, M. (eds) Blood Substitutes. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-2576-8_5
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DOI: https://doi.org/10.1007/978-1-4612-2576-8_5
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