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IGF System in Periimplantation Uterus and Embryonic Development

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Molecular and Cellular Aspects of Periimplantation Processes

Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

The periimplantation period represents a critical point in pregnancy when biological interactions between the embryo and the maternal uterus must be coordinated to ensure a suitable environment for implantation and subsequent development to occur (1). The biochemical processes by which such interactions are initiated, maintained, and regulated are undoubtedly complex and may diverge across species (2, 3); however, the end point remains the development of an intimate and synchronous relationship between the embryo and the uterus on the one hand, and between endometrial stroma and epithelium on the other. One mechanism postulated to be critical to the successful establishment of pregnancy involves the timely production of polypeptide growth factors by the uterus and the developing embryo (4–7). Growth factors are multifunctional proteins that stimulate or inhibit cell proliferation and/or differentiation, ultimately resulting in altered synthesis of proteins with regulatory, structural, and perhaps nutritional functions. In this capacity, growth factors may constitute cellular signals to facilitate the coordinate progression of developmental events in the uterus and embryo.

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Authors
  1. Rosalia C. M. Simmen
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  2. Michael L. Green
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  3. Frank A. Simmen
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Editors and Affiliations

  1. Department of Physiology, University of Kansas Medical Center, Kansas City, KS, 66160, USA

    S. K. Dey Ph.D.

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Simmen, R.C.M., Green, M.L., Simmen, F.A. (1995). IGF System in Periimplantation Uterus and Embryonic Development. In: Dey, S.K. (eds) Molecular and Cellular Aspects of Periimplantation Processes. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2548-5_12

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  • DOI: https://doi.org/10.1007/978-1-4612-2548-5_12

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