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Central and Peripheral Effects of Peptide and Nonpeptide GH Secretagogues on GH Release In Vivo

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Growth Hormone Secretagogues

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

Abstract

Growth hormone (GH) secretion is controlled by the interplay between the secretion of hypothalamic GH releasing factor (GHRF) and somatostatin [somatotropin release inhibiting factor (SRIF)] into hypophysial portal blood (1). Quite separately from the elucidation of the naturally occurring GHRF, Bowers and his colleagues (2,3) developed a different class of GH secretagogues [GH releasing peptides (GHRPs)] of which the most well studied is the hexapeptide GHRP-6. An important property of GHRP-like compounds is that they do not act as GHRF analogues, but show strong synergy with GHRF (4). The slight but significant oral activity of GHRP-6 (5, 6) adds to the potential of such compounds, and has no doubt encouraged the development of more potent peptide (7, 8) and nonpeptidyl GH secretagogues (9, 10). Since these secretagogues are active in man and synergize strongly with GHRF (11–13), they could prove clinically valuable to release GH in patients that respond poorly to GHRF (14).

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Authors
  1. Keith M. Fairhall
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  2. Anita Mynett
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  3. Gregory B. Thomas
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  4. Iain C. A. F. Robinson
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Editors and Affiliations

  1. Pediatric Endocrinology, All Children’s Hospital, 33701, St. PetersBurg, FL, USA

    Barry B. Bercu M.D.  & Richard F. Walker Ph.D.  & 

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© 1996 Springer-Verlag New York, Inc.

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Fairhall, K.M., Mynett, A., Thomas, G.B., Robinson, I.C.A.F. (1996). Central and Peripheral Effects of Peptide and Nonpeptide GH Secretagogues on GH Release In Vivo. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone Secretagogues. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2396-2_15

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  • DOI: https://doi.org/10.1007/978-1-4612-2396-2_15

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7526-8

  • Online ISBN: 978-1-4612-2396-2

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