Abstract
The first proposal for the existence of a growth hormone releasing substance of hypothalamic origin was probably made by Seymour Reichlin in 1959. Reichlin had shown that rats made obese by some (rather extensive) hypothalamic stereotaxic lesions had shorter long bones than controls and that these bones had narrower epiphyseal cartilages. It was to take 23 years eventually to validate the concept by the isolation, amino acid sequencing and reproduction by total synthesis of the hypothalamic growth hormone releasing factor (GHRF).
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© 1996 Springer-Verlag New York, Inc.
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Guillemin, R. (1996). Growth Hormone Releasing Factor: A Brief History of Its Time. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone Secretagogues. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2396-2_1
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DOI: https://doi.org/10.1007/978-1-4612-2396-2_1
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