Abstract
The liver is a unique organ from the kinetic point of view. The endothelium lining the hepatic sinusoids is so highly permeable that the organ presents only a simple barrier to parenchymal cell entry of substrates. The situation is not simple, however, because interposed between the vascular lumen and cell membrane there is an interstitial space that modifies access of molecules to the liver cell surface. The barrier itself is generally not passive. The cell membrane structure exhibits all of the usual characteristics: enzymes facilitate the utilization of substrate or the conversion of materials to products within the liver cell. We will review here how tracer methodology has provided insight into these processes.
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Goresky, C.A., Bach, G.G., Schwab, A.J., Pang, K.S. (1998). Liver Cell Entry In Vivo and Enzymic Conversion. In: Bassingthwaighte, J.B., Linehan, J.H., Goresky, C.A. (eds) Whole Organ Approaches to Cellular Metabolism. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2184-5_13
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DOI: https://doi.org/10.1007/978-1-4612-2184-5_13
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