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Cellular Interactions that Regulate Programmed Cell Death in the Developing Vertebrate Nervous System

  • Chapter
Cell Death and Diseases of the Nervous System

Abstract

The development of individual neurons and the nervous system as a whole are characterized by progressive cellular events involving the gradual attainment of various phenotypes, connectives, and functions. In this context, it is somewhat paradoxical that one of the most fundamental features of the developing nervous system is the widespread death of large numbers of neurons. Characterizing both the cell-cell interactions and molecular mechanisms that regulate neuronal survival during developmental cell death is currently at the forefront of research in developmental neurobiology. First, understanding how neuronal death, like other developmental cellular events such as proliferation, migration, and axon growth confer structure and function to the developing nervous system will provide a deeper understanding of neural and behavioral development in general. Second, vigorously pursuing the cellular interactions and molecular mechanisms that regulate developmental neuronal death may ultimately result in therapeutic strategies for attenuating pathological neuronal death induced by aging, injury, or disease. In fact, such therapeutic approaches have already begun thanks, in part, to several decades of basic research on the role of target-derived signals in regulating the extent of cell death during development. Several putative target-derived neurotrophic factors such as nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF), which rescue neurons from developmental death, are also remarkably successful at preventing neuronal death in animal models of injury and neurodegenerative disease (e.g., refs. 1 and 2). These neurotrophic factors, characterized originally within the framework of basic cell biological research, now for the first time offer the hope of slowing or arresting neuronal death induced by injury, disease, or aging in humans (see chapter by Koliatsos and Mocchetti for a topical discussion of trophic factors).

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Authors
  1. Michael J. Burek
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  2. Ronald W. Oppenheim
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Editors and Affiliations

  1. The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Vassilis E. Koliatsos MD

  2. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

    Rajiv R. Ratan MD, PhD

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Burek, M.J., Oppenheim, R.W. (1999). Cellular Interactions that Regulate Programmed Cell Death in the Developing Vertebrate Nervous System. In: Koliatsos, V.E., Ratan, R.R. (eds) Cell Death and Diseases of the Nervous System. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1602-5_8

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  • DOI: https://doi.org/10.1007/978-1-4612-1602-5_8

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