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Gene Structure and Multiple Regulations of the Ethanol-Inducible Cytochrome P45O2E1 (CYP2E1) Subfamily

  • Chapter
Alcohol and Hormones

Part of the book series: Drug and Alcohol Abuse Reviews ((DAAR,volume 6))

Abstract

Acute and chronic alcohol (ethanol) consumption affects virtually all cellular functions of various tissues, such as brain, liver, digestive systems, immune system, reproductive and endocrine organs, and so forth.1 In liver, ethanol drinking causes alcoholic fatty liver, hepatitis, fibrosis, and cirrhosis. Although the pathoetiological mechanisms of these disease states caused by ethanol consumption are still unknown, several mechanisms have been proposed.2 Ethanol drinking induces microsomal proteins involved in the metabolism of various substrates. The metabolic reactions are predominantly catalyzed by members of the cytochrome P450 system,3 some of which are induced by ethanol or other chemicals. Cytochrome P4502E1 (CYP4502E1) 1 is induced by ethanol and can catalyze metabolism. It is considered a major component of the microsomal ethanol-oxidizing system (MEOS).4The substance of (CYP4502E1) include ethanol, acetaldehyde, acetone, acetol, glycerol, ethylene, glycol, propanol, butanol, dimethylsulfoxide, diethylether, ethyl carbamate, lipid hydroperoxides, acrylamide, benzene, bromobenzene, phenol, aniline, 4-nitrophenol, pyridine, pyrazole, CS2,CCI4,chloroform, chloroethylene, acetaminophen (Tylenol™), halothene, chlorzoxazone, and potent carcinogens of certain nitrosamines, such as N-dimethylnitrosamine.5Some of the substances in turn regulate the activity below.

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Authors and Affiliations

  1. Department of Health and Human Services, Rockville, MD

    Byoung-Joon Song

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  1. Byoung-Joon Song
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  1. University of Arizona, Tucson, Arizona, USA

    Ronald R. Watson

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© 1995 Springer Science+Business Media New York

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Song, BJ. (1995). Gene Structure and Multiple Regulations of the Ethanol-Inducible Cytochrome P45O2E1 (CYP2E1) Subfamily. In: Watson, R.R. (eds) Alcohol and Hormones. Drug and Alcohol Abuse Reviews, vol 6. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0243-1_9

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  • DOI: https://doi.org/10.1007/978-1-4612-0243-1_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6678-5

  • Online ISBN: 978-1-4612-0243-1

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