Abstract
Many current studies in heart development appropriately emphasize identifying new genes or genetic “wiring” In the last 5 years, dozens, if not a hundred or more, potential regulatory genes have been identified as being expressed in the heart and many of these have been or are being used to create animal models in which to study the function of these genes. Thus, what we have today is a rapidly growing number of genes and genetically created animals. While the identification of new genes expressed in the heart is exciting and always with anticipation of being an upstream master regulator (e.g., a “myo–H” Miner et al, 1992) the fact remains that the heart is the outcome of many cellular processes operating at different time points and at different levels of structural complexity. Moreover, as described above, not all cells in the heart are derived from the heart–forming fields and as many as three heart fields may be required to sustain the progressive formation of segments. Thus, to fully exploit the wealth of new genetic information, what is needed are studies that can provide an understanding of how fundamental, cellular interactions are integrated over time to engender changes in gene expression that direct the morphogenetic processes required for the formation of a tubular heart and its subsequent remodeling into a four–chambered organ. The chapters presented in this volume present new data and/or review studies that provide insight for mechanistically interpreting (or hypothesizing) structural or functional consequences of those gene activities that can continue to move the field of cardiac morphogenesis.
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Markwald, R.R., Wessels, A. (2001). Overview of Heart Development. In: Tomanek, R.J., Runyan, R.B. (eds) Formation of the Heart and Its Regulation. Cardiovascular Molecular Morphogenesis. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-0207-3_1
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