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Endothelial and Smooth-Muscle Cells

  • Chapter
Diseases of the Arterial Wall

Abstract

Normal muscular and elastic arteries consist of three morphologically distinct layers [20,325] which will be considered in more detail in Chap.4. The intima consists of a narrow region bounded on the luminal side by a single continuous layer of endothelial cells and peripherally by a fenestrated sheet of elastic fibres, the internal elastic lamina. Between these boundaries are smooth-muscle cells and various components of extracellular connective-tissue matrix. With increasing age in man, intimal smooth-muscle cells and extracellular matrix components accumulate slowly and generally at a uniform rate, except in certain areas where nodular accumulations called “cushions” develop (see Chap 3). Why so few smooth-muscle cells are initially present in the intima, and why the number of these cells normally increases with age, are important questions that remain to be answered.

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Authors
  1. I. Hüttner
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  2. O. Kocher
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  3. G. Gabbiani
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Editors and Affiliations

  1. Service d’Anatomie Pathologique et Unité de Recherche sur la Pathologie Rénale et Vasculaire, INSERM U28, Paris, France

    Jean-Pierre Camilleri (Professeur) (Professeur)

  2. Department of Morbid Anatomy, Institute of Pathology, The London Hospital, Whitechapel, London, E1 1BB, UK

    Colin L. Berry (Professor) (Professor)

  3. Service de Médecine Interne et de Pathologie Vasculaire, Hôpital Broussais, Paris, France

    Jean-Noël Fiessinger (Professeur) (Professeur)

  4. Service de Néphrologie et Unité de Recherche sur la Pathologie Rénale et Vasculaire, INSERM U28, Hôpital Broussais, Paris, France

    Jean Bariéty (Professeur) (Professeur)

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Hüttner, I., Kocher, O., Gabbiani, G. (1989). Endothelial and Smooth-Muscle Cells. In: Camilleri, JP., Berry, C.L., Fiessinger, JN., Bariéty, J. (eds) Diseases of the Arterial Wall. Springer, London. https://doi.org/10.1007/978-1-4471-1464-2_1

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