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Cell Cycle, Budding Yeast

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Encyclopedia of Systems Biology

Synonyms

Saccharomyces cerevisiae

Definition

The cell cycle of budding yeast has become a hallmark problem of molecular systems biology for a number of reasons. (1) The cycle of DNA replication, mitosis, and cell division is crucial to all aspects of biological growth, development, and reproduction. (2) The genes and pathways for cell cycle control seem to be very similar in all eukaryotes, including mammals. (3) Budding yeast is exceptionally good for genetic analysis of cell cycle controls because it can proliferate as haploid cells, and its genetic makeup can be easily altered by standard tools of molecular genetics. For this reason, a great deal is known about the molecular machinery regulating the events of the budding yeast cell cycle. (4) The machinery is very complicated, and its properties cannot be worked out reliably by intuitive reasoning alone. (5) Comprehensive mathematical models of the budding yeast cell cycle have been built and tested against a wide range of...

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References

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Author information

Authors and Affiliations

  1. Department of Biological Sciences, Virginia Polytechnic Institute and State University, Derring Hall, Blacksburg, VA, 24061, USA

    Dr. John J. Tyson & Katherine C. Chen

  2. Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford, UK

    Béla Novák

Authors
  1. Dr. John J. Tyson
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  2. Katherine C. Chen
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  3. Béla Novák
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Corresponding author

Correspondence to John J. Tyson .

Editor information

Editors and Affiliations

  1. Biomedical Sciences Research Institute, University of Ulster, Coleraine, UK

    Werner Dubitzky

  2. Department of Computer Science, University of Rostock, Rostock, Germany

    Olaf Wolkenhauer

  3. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea

    Kwang-Hyun Cho

  4. Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA

    Hiroki Yokota

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Tyson, J.J., Chen, K.C., Novák, B. (2013). Cell Cycle, Budding Yeast. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_16

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