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Kainate Receptors with a Metabotropic Signature Enhance Hippocampal Excitability by Regulating the Slow After-Hyperpolarization in CA3 Pyramidal Neurons

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Kainate Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 717))

Abstract

Most of our knowledge of the synaptic function of kainate receptors stems from a detailed analysis of synaptic transmission between dentate granule cells and CA3 pyramidal neurons, where kainate receptors mediate a slow excitatory current with integrative properties ideally suited for repetitive neuronal firing. Besides this well characterized ionotropic effect of kainate receptors, they can also enhance neuronal excitability by inhibiting the slow Ca2+ activated K+ current IsAHP via a G-protein coupled mechanism. This phenomenon is associated with Ca2+ mobilization and protein-kinase activation and ultimately leads to modulation of ion channels responsible for intrinsic electrical properties such as firing adaptation. The significance for CNS function of these newly emerging metabotropic kainate receptors is poorly understood and as yet proteomic analysis of kainate receptors has yielded little information on signaling molecules associated with the kainate receptor ionophore. This chapter covers the key findings that have led to the proposal that high-affinity postsynaptic kainate receptors trigger a form of metabotropic signaling regulating IsAH P and neuronal firing in CA3 hippocampal neurons.

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Authors and Affiliations

  1. Department of Pharmacology, The School of Pharmacy, University of London, Brunswick Square, London, WC1N 1AX, UK

    Arnaud Ruiz

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  1. Arnaud Ruiz
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Correspondence to Arnaud Ruiz .

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  1. Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain

    Antonio Rodríguez-Moreno PhD

  2. Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK

    Talvinder S. Sihra PhD

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Ruiz, A. (2011). Kainate Receptors with a Metabotropic Signature Enhance Hippocampal Excitability by Regulating the Slow After-Hyperpolarization in CA3 Pyramidal Neurons. In: Rodríguez-Moreno, A., Sihra, T.S. (eds) Kainate Receptors. Advances in Experimental Medicine and Biology, vol 717. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9557-5_6

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