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Cancer Cells Homing to Bone: The Significance of Chemotaxis and Cell Adhesion

  • Chapter
The Biology of Skeletal Metastases

Part of the book series: Cancer Treatment and Research ((CTAR,volume 118))

Abstract

Cancer cell metastasis is a complex process involving several well-characterized steps. To metastasize successfully, tumor cells must first detach from a primary mass, enter the blood circulation or lymphatics. Subsequently, tumors must home to a particular organ, adhere to the endothelium lining the capillaries of that organ, exit the circulation where they must adhere to organ-specific extra-cellular matrix (ECM) components to begin new growth in an foreign environment (Geldof, 1997). Although the metastatic pattern of some cancers may be explained by anatomy, such as the pattern of efferent venous and lymphatic drainage, anatomy does not account for the metastatic pattern of all cancers (Nicolson et al., 1984). This suggests that other factors contribute significantly to the metastatic fate of cancer cells.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Delaware, Newark, DE, USA

    Carlton R. Cooper & Robert A. Sikes

  2. Department of Urology, University of Virginia Health System, Charlottesville, VA, USA

    Brian E. Nicholson

  3. Periodontics/Prevention/Geriatrics, University of Michigan, Ann Arbor, MI, USA

    Yan-Xi Sun & Russell S. Taichman

  4. Departments of Internal Medicine and Surgery, University of Michgian, Ann Arbor, MI, USA

    Kenneth J. Pienta

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Editors and Affiliations

  1. University of Michigan Comprehensive Cancer Center University of Michigan School of Medicine, University of Michigan, Ann Arbor, Michigan, USA

    Evan T. Keller DVM, PhD (Associate Professor of Urology, Comparative Medicine and Pathology) (Associate Professor of Urology, Comparative Medicine and Pathology)

  2. Emory University School of Medicine, Emory University, Atlanta, Georgia, USA

    Leland W. K. Chung PhD (Professor of Urology, Hematology/Oncology, Biochemistry and the Winship Cancer Institute) (Professor of Urology, Hematology/Oncology, Biochemistry and the Winship Cancer Institute)

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Cooper, C.R., Sikes, R.A., Nicholson, B.E., Sun, YX., Pienta, K.J., Taichman, R.S. (2004). Cancer Cells Homing to Bone: The Significance of Chemotaxis and Cell Adhesion. In: Keller, E.T., Chung, L.W.K. (eds) The Biology of Skeletal Metastases. Cancer Treatment and Research, vol 118. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9129-4_12

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