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The Basic Biology of Metastasis

  • Chapter
The Biology of Skeletal Metastases

Part of the book series: Cancer Treatment and Research ((CTAR,volume 118))

Abstract

It is the ability to metastasize that makes cancer a fatal disease. Of the 555,500 cancer-related deaths expected this year in the United States, the vast majority are due to the development of metastatic disease rather than the primary tumor (Jemal et al., 2002). Although treatment is available for patients with metastatic cancer, options are limited and responses can be quite variable. Furthermore, complete remissions tend to be limited in both scope and duration.

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References

  • Al-Mehdi, A.B., Tozawa, K., Fisher, A.B., Shientag, L., Lee, A. and Muschel, RJ. (2000) Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nature Medicine, 6, 100–102.

    Article  PubMed  CAS  Google Scholar 

  • Aslakson, C.J., Rak, J.W., Miller, B.E. and Miller, F.R. (1991) Differential influence of organ site on three subpopulations of a single mouse mammary tumor at two distinct steps in metastasis. International Journal of Cancer, 47, 466–472.

    Article  CAS  Google Scholar 

  • Athanasou, N.A. and Quinn, J.M. (1992) Human tumour-associated macrophages are capable of bone resorption. British Journal of Cancer, 65, 523–526.

    Article  PubMed  CAS  Google Scholar 

  • Balkwill, F. (2003) Chemokine biology in cancer. Seminars in Immunology, 15, 49–55.

    Article  PubMed  CAS  Google Scholar 

  • Beckner, M.E. (1999) Factors promoting tumor angiogenesis. Cancer Investigation, 17, 594–623.

    Article  PubMed  CAS  Google Scholar 

  • Bockmann, B., Grill, H.J. and Giesing, M. (2001) Molecular characterization of minimal residual cancer cells in patients with solid tumors. Biomolecular Engineering, 17, 95–111.

    Article  PubMed  CAS  Google Scholar 

  • Chackal-Roy, M., Niemeyer, C., Moore, M. and Zetter, B.R. (1989) Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow. Journal of Clinical Investigation, 84, 43–50.

    Article  PubMed  CAS  Google Scholar 

  • Chambers, A.F., Groom, A.C. and MacDonald, I.C. (2002) Dissemination and growth of cancer cells in metastatic sites. Nature Reviews Cancer, 2, 563–572.

    Article  PubMed  CAS  Google Scholar 

  • Chambers, A.F., MacDonald, I.C., Schmidt, E.E., Morris, V.L. and Groom, A.C. (2000) Clinical targets for anti-metastasis therapy. Advances in Cancer Research, 79, 91–121.

    Article  PubMed  CAS  Google Scholar 

  • Chambers, A.F. and Matrisian, L.M. (1997) Changing views of the role of matrix metalloproteinases in metastasis. Journal of the National Cancer Institute, 89, 1260–1270.

    Article  PubMed  CAS  Google Scholar 

  • Cher, M.L., de Oliveira, J.G., Beaman, A.A., Nemeth, J.A., Hussain, M. and Wood, D.P., Jr. (1999) Cellular proliferation and prevalence of micrometastatic cells in the bone marrow of patients with clinically localized prostate cancer. Clinical Cancer Research, 5, 2421–2425.

    PubMed  CAS  Google Scholar 

  • Christiano, A.P., Yoshida, B.A., Dubauskas, Z., Sokoloff, M. and Rinker-Schaeffer, C.W. (2000) Development of markers of prostate cancer metastasis. Review and perspective. Urological Oncology, 5, 217–223.

    Article  Google Scholar 

  • Clark, E.A., Golub, T.R., Lander, E.S. and Hynes, R.O. (2000) Genomic analysis of metastasis reveals an essential role for RhoC. Nature, 406, 532–535.

    Article  PubMed  CAS  Google Scholar 

  • Corey, E., Arfman, E.W., Oswin, M.M., Melchior, S.W., Tindall, D.J., Young, C.Y., Ellis, W.J. and Vessella, R.L. (1997) Detection of circulating prostate cells by reverse transcriptase-polymerase chain reaction of human glandular kallikrein (hK2) and prostatespecific antigen (PSA) messages. Urology, 50, 184–188.

    Article  PubMed  CAS  Google Scholar 

  • Debies, M.T. and Welch, D.R. (2001) Genetic basis of human breast cancer metastasis. Journal of Mammary Gland Biology and Neoplasia, 6, 441–451.

    Article  PubMed  CAS  Google Scholar 

  • Deguchi, T., Yang, M., Ehara, H., Ito, S., Nishino, Y., Takahashi, Y., Ito, Y., Shimokawa, K., Tanaka, T., Imaeda, T., Doi, T. and Kawada, Y. (1997) Detection of micrometastatic prostate cancer cells in the bone marrow of patients with prostate cancer. British Journal of Cancer, 75, 634–638.

    Article  PubMed  CAS  Google Scholar 

  • Dong, J.T., Lamb, P.W., Rinker-Schaeffer, C.W., Vukanovic, J., Ichikawa, T., Isaacs, J.T. and Barrett, J.C. (1995) KAI1, a metastasis suppressor gene for prostate cancer on human chromosome l lpl l.2. Science, 268, 884–886.

    Article  PubMed  CAS  Google Scholar 

  • Ellis, W.J., Vessella, R.L., Corey, E., Arfman, E.W., Oswin, M.M., Melchior, S. and Lange, P.H. (1998) The value of a reverse transcriptase polymerase chain reaction assay in preoperative staging and followup of patients with prostate cancer. Journal of Urology, 159, 1134–1138.

    Article  PubMed  CAS  Google Scholar 

  • Fidler, I.J. (1970) Metastasis: guantitative analysis of distribution and fate of tumor embolilabeled with 125 I-5-iodo-2’-deoxyuridine. Journal of the National Cancer Institute, 45, 773–782.

    PubMed  CAS  Google Scholar 

  • Fidler, I.J. (2001) Seed and soil revisited: contribution of the organ microenvironment to cancer metastasis. Surgical Oncology Clinical N Am, 10, 257–269, vii-viiii.

    CAS  Google Scholar 

  • Folkman, J. (2002) Role of angiogenesis in tumor growth and metastasis. Seminars in Oncology, 29, 15–18.

    PubMed  CAS  Google Scholar 

  • Fornaro, M., Manes, T. and Languino, L.R. (2001) Integrins and prostate cancer metastases. Cancer Metastasis Reviews, 20, 321–331.

    Article  PubMed  CAS  Google Scholar 

  • Funke, I. and Schraut, W. (1998) Meta-analyses of studies on bone marrow micrometastases: an independent prognostic impact remains to be substantiated. Journal of Clinical Oncology, 16, 557–566.

    PubMed  CAS  Google Scholar 

  • Gao, A.C., Lou, W., Dong, J.T. and Isaacs, J.T. (1997) CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 1 1p l 3. Cancer Research, 57, 846–849.

    PubMed  CAS  Google Scholar 

  • Gleave, M., Hsieh, J.T., Gao, CA., von Eschenbach, A.C. and Chung, L.W. (1991) Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts. Cancer Research, 51, 3753–3761.

    PubMed  CAS  Google Scholar 

  • Goldberg, S.F., Harms, J.F., Quon, K. and Welch, D.R. (1999) Metastasis-suppressed C8161 melanoma cells arrest in lung but fail to proliferate. Clinical Experimental Metastasis, 17, 601–607.

    Article  PubMed  CAS  Google Scholar 

  • Goldberg, S.F., Miele, M.E., Hatta, N., Takata, M., Paquette-Straub, C., Freedman, L.P. and Welch, D.R. (2003) Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP. Cancer Research, 63, 432–440.

    PubMed  CAS  Google Scholar 

  • Guan, R.J., Ford, H.L., Fu, Y., Li, Y., Shaw, L.M. and Pardee, A.B. (2000) Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Cancer Research, 60, 749–755.

    PubMed  CAS  Google Scholar 

  • Guise, T.A., Yin, J.J., Taylor, S.D., Kumagai, Y., Dallas, M., Boyce, B.F., Yoneda, T. and Mundy, G.R. (1996) Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. Journal of Clinical Investigation, 98, 1544–1549.

    Article  PubMed  CAS  Google Scholar 

  • Hagedorn, M. and Bikfalvi, A. (2000) Target molecules for anti-angiogenic therapy: from basic research to clinical trials. Critical Reviews in Oncology Hematology, 34, 89–110.

    Article  CAS  Google Scholar 

  • Hart, I.R. and Fidler, I.J. (1980) Role of organ selectivity in the determination of metastatic patterns of B16 melanoma. Cancer Research, 40, 2281–2287.

    PubMed  CAS  Google Scholar 

  • Hart, I.R., Talmadge, J.E. and Fidler, I.J. (1981) Metastatic behavior of a murine reticulum cell sarcoma exhibiting organ-specific growth. Cancer Research, 41, 1281–1287.

    PubMed  CAS  Google Scholar 

  • Hermanek, P. (1999) Disseminated tumor cells versus micrometastasis: definitions and problems. Anticancer Research, 19, 2771–2774.

    PubMed  CAS  Google Scholar 

  • Jauch, K.W., Heiss, M.M., Gruetzner, U., Funke, I., Pantel, K., Babic, R., Eissner, H.J., Riethmueller, G. and Schildberg, F.W. (1996) Prognostic significance of bone marrow micrometastases in patients with gastric cancer. Journal of Clinical Oncology, 14, 1810–1817.

    PubMed  CAS  Google Scholar 

  • Jemal, A., Thomas, A., Murray, T. and Thun, M. (2002) Cancer statistics, 2002. CA Cancer Journal for Clinicians, 52, 23–47.

    Article  Google Scholar 

  • Kauffman, E.C., Robinson, V.L., Stadler, W.M., Sokoloff, M.H. and Rinker-Schaeffer, C.W. (2003) Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site. Journal of Urology, 169, 1122–1133.

    Article  PubMed  Google Scholar 

  • Kuo, T.H., Kubota, T., Watanabe, M., Furukawa, T., Teramoto, T., Ishibiki, K., Kitajima, M., Moossa, A.R., Penman, S. and Hoffman, R.M. (1995) Liver colonization competence governs colon cancer metastasis. Proceedings of the National Academy of Sciences USA, 92,12085–12089.

    Article  CAS  Google Scholar 

  • Laferriere, J., Houle, F. and Huot, J. (2002) Regulation of the metastatic process by E-selectin and stress-activated protein kinase-2/p38. Annals of the New York Academy of Sciences, 973, 562–572.

    Article  PubMed  CAS  Google Scholar 

  • Lafrenie, R.M., Podor, T.J., Buchanan, M.R. and Orr, F.W. (1992) Up-regulated biosynthesis and expression of endothelial cell vitronectin receptor enhances cancer cell adhesion. Cancer Research, 52, 2202–2208.

    PubMed  CAS  Google Scholar 

  • Lang, S.H., Miller, W.R. and Habib, F.K. (1995) Stimulation of human prostate cancer cell lines by factors present in human osteoblast-like cells but not in bone marrow. Prostate, 27,287–293.

    Article  PubMed  CAS  Google Scholar 

  • Lee, H.L., Pienta, K.J., Kim, W.J. and Cooper, C.R. (2003) The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro. Internationaljournal of Oncology, 22, 921–926.

    CAS  Google Scholar 

  • Leone, A., Flatow, U., King, C.R., Sandeen, M.A., Margulies, I.M., Liotta, L.A. and Steeg, P.S. (1991) Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell, 65, 25–35.

    Article  PubMed  CAS  Google Scholar 

  • Liekens, S., De Clercq, E. and Neyts, J. (2001) Angiogenesis: regulators and clinical applications. Biochemical Pharmacology, 61, 253–270.

    Article  PubMed  CAS  Google Scholar 

  • Lindberg, R. (1972) Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer, 29, 1446–1449.

    Article  PubMed  CAS  Google Scholar 

  • Lindemann, F., Schlimok, G., Dirschedl, P., Witte, J. and Riethmuller, G. (1992) Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet, 340, 685–689.

    Article  PubMed  CAS  Google Scholar 

  • Luzzi, K.J., MacDonald, I.C., Schmidt, E.E., Kerkvliet, N., Morris, V.L., Chambers, A.F. and Groom, A.C. (1998) Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. American Journal of Pathology, 153, 865–873.

    Article  PubMed  CAS  Google Scholar 

  • Maniotis, A.J., Folberg, R., Hess, A., Seftor, E.A., Gardner, L.M., Pe’er, J., Trent, J.M., Meltzer, P.S. and Hendrix, M.J. (1999) Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. American Journal of Pathology, 155, 739–752.

    Article  PubMed  CAS  Google Scholar 

  • Mannori, G., Santero, D., Carter, L., Corless, C., Nelson, R.M. and Bevilacqua, M.P. (1997) Inhibition of colon carcinoma cell lung colony formation by a soluble form of E-selectin. American Journal of Pathology, 151, 233–243.

    PubMed  CAS  Google Scholar 

  • Melchior, S.W., Corey, E., Ellis, W.J., Ross, A.A., Layton, T.J., Oswin, M.M., Lange, P.H. and Vessella, R.L. (1997) Early tumor cell dissemination in patients with clinically localized carcinoma of the prostate. Clinical Cancer Research, 3, 249–256.

    PubMed  CAS  Google Scholar 

  • Mercurio, A.M., Bachelder, R.E., Rabinovitz, I., O'Connor, K.L., Tani, T. and Shaw, L.M. (2001) The metastatic Odyssey: the integrin connection. Surgical Oncology Clinical N Am, 10, 313–328, viii-ix.

    CAS  Google Scholar 

  • Miyasaka, M. (1995) Cancer metastasis and adhesion molecules. Clinical Orthopaedics, 10–18.

    Google Scholar 

  • Mizejewski, G.J. (1999) Role of integrins in cancer: survey of expression patterns. Proceedings of the Society for Experimental Biology and Medicine, 222, 124–138.

    Article  PubMed  CAS  Google Scholar 

  • Morris, V.L., Koop, S., MacDonald, I.C., Schmidt, E.E., Grattan, M., Percy, D., Chambers, A.F. and Groom, A.C. (1994) Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth. Clinical Experimental Metastasis, 12, 357–367.

    Article  PubMed  CAS  Google Scholar 

  • Muller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S.N., Barrera, J.L., Mohar, A., Verastegui, E. and Zlotnik, A. (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature, 410, 50–56.

    Article  PubMed  CAS  Google Scholar 

  • Mundy, G.R. (1997) Mechanisms of bone metastasis. Cancer, 80, 1546–1556.

    Article  PubMed  CAS  Google Scholar 

  • Mundy, G.R. (2002) Metastasis to bone: causes, consequences and therapeutic opportunities. Nature Reviews Cancer, 2, 584–593.

    Article  PubMed  CAS  Google Scholar 

  • Naumov, G.N., MacDonald, I.C., Chambers, A.F. and Groom, A.C. (2001) Solitary cancer cells as a possible source of tumour dormancy? Seminars in Cancer Biology, 11, 271–276.

    Article  PubMed  CAS  Google Scholar 

  • Nemeth, J.A., Harb, J.F., Barroso, U., Jr., He, Z., Grignon, DJ. and Cher, M.L. (1999) Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone. Cancer Research, 59, 1987–1993.

    PubMed  CAS  Google Scholar 

  • Nemeth, J.A., Yousif, R., Herzog, M., Che, M., Upadhyay, J., Shekarriz, B., Bhagat, S., Mullins, C., Fridman, R. and Cher, M.L. (2002) Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis. Journal of the National Cancer Institute, 94, 17–25.

    Article  PubMed  CAS  Google Scholar 

  • Nicolson, G.L. (1988) Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites. Biochimica Biophysica Acta, 948, 175–224.

    CAS  Google Scholar 

  • Nishijima, Y., Uchida, K., Koiso, K. and Nemoto, R. (1992) Clinical significance of the vertebral vein in prostate cancer metastasis. Advances in Experimental Medicine and Biology, 324, 93–100.

    Article  PubMed  CAS  Google Scholar 

  • Nouri, A.M., Hussain, R.F., Dos Santos, A.V. and Oliver, R.T. (1996) Defective expression of adhesion molecules on human bladder tumour and human tumour cell lines. Urology Internationalis, 56, 6–12.

    Article  CAS  Google Scholar 

  • Okegawa, T., Li, Y., Pong, R.C. and Hsieh, J.T. (2002) Cell adhesion proteins as tumor suppressors. Journal of Urology, 167, 1836–1843.

    Article  PubMed  CAS  Google Scholar 

  • Orr, F.W., Sanchez-Sweatman, O.H., Kostenuik, P. and Singh, G. (1995) Tumor-bone interactions in skeletal metastasis. Clinical Orthopaedics, 19–33.

    Google Scholar 

  • Paul, R., Ewing, C.M., Jarrard, D.F. and Isaacs, W.B. (1997) The cadherin cell-cell adhesion pathway in prostate cancer progression. British Journal of Urology, 79Suppl 1, 37–43.

    PubMed  Google Scholar 

  • Perl, A.K., Dahl, U., Wilgenbus, P., Cremer, H., Semb, H. and Christofori, G. (1999) Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Nature Medicine, 5, 286–291.

    Article  PubMed  CAS  Google Scholar 

  • Poste, G. and Fidler, I.J. (1980) The pathogenesis of cancer metastasis. Nature, 283, 139–146.

    Article  PubMed  CAS  Google Scholar 

  • Potter, K.M., Juacaba, S.F., Price, J.E. and Tarin, D. (1983) Observations on organ distribution of fluorescein-labelled tumour cells released intravascularly. Invasion and Metastasis, 3, 221–233.

    CAS  Google Scholar 

  • Quinn, J.M. and Athanasou, N.A. (1992) Tumour infiltrating macrophages are capable of bone resorption. Journal of Cell Science, 101 (Pt 3), 681–686.

    PubMed  Google Scholar 

  • Radinsky, R. (1995) Modulation of tumor cell gene expression and phenotype by the organspecific metastatic environment. Cancer Metastasis Reviews, 14, 323–338.

    Article  PubMed  CAS  Google Scholar 

  • Riethmuller, G. and Klein, C.A. (2001) Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients. Seminars in Cancer Biology, 11, 307–311.

    Article  PubMed  CAS  Google Scholar 

  • Rusciano, D., Welch, D. R., Burger, M. M. (2000) “ Laboratory Techniques in Biochemistry and Molecular Biology; Cancer Metastasis” In Vitro and In Vivo Experimental Approaches. Edited by P.C. van der Vliet and S. Pillai. Elsevier Press.

    Google Scholar 

  • Sawada, R., Tsuboi, S. and Fukuda, M. (1994) Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials. Journal of Biological Chemistry, 269, 1425–1431.

    PubMed  CAS  Google Scholar 

  • Seraj, M.J., Harding, M.A., Gildea, J.J., Welch, D.R. and Theodorescu, D. (2000) The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines. Clinical and Experimental Metastasis, 18, 519–525.

    Article  PubMed  CAS  Google Scholar 

  • Shevde, L.A., Samant, R.S., Goldberg, S.F., Sikaneta, T., Alessandrini, A., Donahue, H.J., Mauger, D.T. and Welch, D.R. (2002) Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. Experimental Cell Research, 273, 229–239.

    Article  PubMed  CAS  Google Scholar 

  • Shevde, L.A., and Welch, D.R. (2003) Metastasis suppressor pathways-an evolving paradigm. Cancer Letters, In Press.

    Google Scholar 

  • Sokoloff, M.H., Tso, C.L., Kaboo, R., Nelson, S., Ko, J., Dorey, F., Figlin, R.A., Pang, S., deKernion, J. and Belldegrun, A. (1996) Quantitative polymerase chain reaction does not improve preoperative prostate cancer staging: a clinicopathological molecular analysis of 121 patients. Journal of Urology, 156, 1560–1566.

    Article  PubMed  CAS  Google Scholar 

  • Steeg, P.S. (2003) Metastasis suppressors alter the signal transduction of cancer cells. Nature Reviews Cancer, 3, 55–63.

    Article  PubMed  CAS  Google Scholar 

  • Su, S.L., Boynton, A.L., Holmes, E.H., Elgamal, A.A. and Murphy, G.P. (2000) Detection of extraprostatic prostate cells utilizing reverse transcription-polymerase chain reaction. Seminars in Surgical Oncology, 18, 17–28.

    Article  PubMed  CAS  Google Scholar 

  • Thorban, S., Roder, J.D., Nekarda, H., Funk, A., Pantel, K. and Siewert, J.R. (1996) Disseminated epithelial tumor cells in bone marrow of patients with esophageal cancer: detection and prognostic significance. World Journal of Surgery, 20, 567–572; discussion 572-563.

    Article  PubMed  CAS  Google Scholar 

  • Trusolino, L. and Comoglio, P.M. (2002) Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nature Reviews Cancer, 2, 289–300.

    Article  PubMed  CAS  Google Scholar 

  • Varghese, H.J., Davidson, M.T., MacDonald, I.C., Wilson, S.M., Nadkarni, K.V., Groom, A.C. and Chambers, A.F. (2002) Activated ras regulates the proliferation/apoptosis balance and early survival of developing micrometastases. Cancer Research, 62, 887–891.

    PubMed  CAS  Google Scholar 

  • Vleminckx, K., Vakaet, L., Jr., Mareel, M., Fiers, W. and van Roy, F. (1991) Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell, 66,107–119.

    Article  PubMed  CAS  Google Scholar 

  • Weiss, L. (1990) Metastatic inefficiency. Advances in Cancer Research, 54, 159–211.

    Article  PubMed  CAS  Google Scholar 

  • Wood, D.P., Jr. and Banerjee, M. (1997) Presence of circulating prostate cells in the bone marrow of patients undergoing radical prostatectomy is predictive of disease-free survival. Journal of Clinical Oncology, 15, 3451–3457.

    PubMed  Google Scholar 

  • Wood, D.P., Jr., Banks, E.R., Humphreys, S., McRoberts, J.W. and Rangnekar, V.M. (1994) Identification of bone marrow micrometastases in patients with prostate cancer. Cancer, 74, 2533–2540.

    Article  PubMed  Google Scholar 

  • Wood, D.P., Jr., Beaman, A., Banerjee, M., Powell, I., Pontes, E. and Cher, M.L. (1998) Effect of neoadjuvant androgen deprivation on circulating prostate cells in the bone marrow of men undergoing radical prostatectomy. Clinical Cancer Research, 4, 2119–2123.

    PubMed  CAS  Google Scholar 

  • Xia, W., Unger, P., Miller, L., Nelson, J. and Gelman, I.H. (2001) The Src-suppressed C kinase substrate, SSeCKS, is a potential metastasis inhibitor in prostate cancer. Cancer Research, 61, 5644–5651.

    PubMed  CAS  Google Scholar 

  • Yoshida, B.A., Dubauskas, Z., Chekmareva, M.A., Christiano, T.R., Stadler, W.M. and Rinker-Schaeffer, C.W. (1999) Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17. Cancer Research, 59, 5483–5487.

    PubMed  CAS  Google Scholar 

  • Yoshida, B.A., Sokoloff, M.M., Welch, D.R. and Rinker-Schaeffer, C.W. (2000) Metastasissuppressor genes: a review and perspective on an emerging field. Journal of the National Cancer Institute, 92, 1717–1730.

    Article  PubMed  CAS  Google Scholar 

  • Zetter, B.R. (1993) Adhesion molecules in tumor metastasis. Seminars in Cancer Biology, 4, 219–229.

    PubMed  CAS  Google Scholar 

  • Zetter, B.R. (1998) Angiogenesis and tumor metastasis. Annual Reviews in Medicine, 49, 407–424.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Section of Urology, Department of Surgery, The University of Chicago, Chicago, USA

    Victoria L. Robinson, Eric C. Kauffman, Mitchell H. Sokoloff & Carrie W. Rinker-Schaeffer

  2. Section of Hematotogy/Oncology, Department of Medicine, The University of Chicago, Chicago, USA

    Carrie W. Rinker-Schaeffer

  3. The Genitourinary Oncology Research Program, The University of Chicago Comprehensive Cancer Research Center, Chicago, USA

    Carrie W. Rinker-Schaeffer

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  1. Victoria L. Robinson
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Editors and Affiliations

  1. University of Michigan Comprehensive Cancer Center University of Michigan School of Medicine, University of Michigan, Ann Arbor, Michigan, USA

    Evan T. Keller DVM, PhD (Associate Professor of Urology, Comparative Medicine and Pathology) (Associate Professor of Urology, Comparative Medicine and Pathology)

  2. Emory University School of Medicine, Emory University, Atlanta, Georgia, USA

    Leland W. K. Chung PhD (Professor of Urology, Hematology/Oncology, Biochemistry and the Winship Cancer Institute) (Professor of Urology, Hematology/Oncology, Biochemistry and the Winship Cancer Institute)

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Robinson, V.L., Kauffman, E.C., Sokoloff, M.H., Rinker-Schaeffer, C.W. (2004). The Basic Biology of Metastasis. In: Keller, E.T., Chung, L.W.K. (eds) The Biology of Skeletal Metastases. Cancer Treatment and Research, vol 118. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9129-4_1

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