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Regulation of Pseudomonas Aeruginosa Exotoxin a Synthesis

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Virulence and Gene Regulation

Abstract

Exotoxin A (ETA) is one of the most toxic virulence factors produced by Pseudomonas aeruginosa 72: Both clinical and experimental animal studies indicate clearly the importance of ETA in the pathogenesis of different P. aeruginosa infections. Most P. aeruginosa clinical isolates produce ETA9, 23, 47. In addition, infection with ETA-producing P. aeruginosa strains was shown to be significantly associated with mortality due to P. aeruginosa bacteremia98. Furthermore, survival of patients with P. aeruginosa bacteremia correlated with high ETA antibody titers in those patients98, 99. Examination of patients with cystic fibrosis (CF) that were chronically infected with P. aeruginosa showed the presence of an increased titer of ETA antibody57. In addition, mortality among P. aeruginosa infected CF-patients was associated with increased levels of ETA and LPS antibodies together with the presence of immu necomplexes and complement activation84. Recent analysis of RNA extracted from sputa of CF patients revealed that the ETA gene (toxA) was expressed in the lung of CF patients infected with P. aeruginosa 105.

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  1. Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX, 79430, USA

    Abdul N. Hamood, Jane A. Colmer-Hamood & Nancy L. Carty

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  1. Abdul N. Hamood
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  2. Jane A. Colmer-Hamood
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  1. CSIC, Granada, Spain

    Juan-Luis Ramos

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Hamood, A.N., Colmer-Hamood, J.A., Carty, N.L. (2004). Regulation of Pseudomonas Aeruginosa Exotoxin a Synthesis. In: Ramos, JL. (eds) Virulence and Gene Regulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9084-6_14

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