Skip to main content
SpringerLink
Log in

A Paradigm for Gene Regulation: Inflammation, NF-κB and PPAR

  • Conference paper
Peroxisomal Disorders and Regulation of Genes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 544))

Abstract

Inflammation is a rather general term for a variety of diseases, which appear as different affections depending on the tissue involved. They share a number of common characteristics, among which the expression and secretion of inflammatory cytokines and chemokines.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agalioti, T., Lomvardas, S., Parekh, B., Yie, J., Maniatis, T., and Thanos, D., 2000, Ordered recruitment of chromatin modifying and general transcription factors to the IFN-p promoter. Cell 103: 667–678.

    Article  CAS  PubMed  Google Scholar 

  • Agalioti, T., Chen, G., and Thanos, D., 2002, Deciphering the transcriptional histone acetylation code for a human gene. Cell 111: 381–392.

    Article  CAS  PubMed  Google Scholar 

  • Akimaru, H., Hou, D. X., and Ishii, S., 1997, Drosophila CBP is required for dorsal-dependent twist gene expression. Nat. Genet. 17:211–214.

    Article  CAS  PubMed  Google Scholar 

  • Algarte, M., Kwon, H., Genin, P., and Hiscott, J., 1999, Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kB and Spl that regulates the IkBoi promoter. Mol. Cell. Biol. 19: 6140–6153.

    CAS  PubMed  Google Scholar 

  • Archer, S. Y., and Hodin, R. A., 1999, Histone acetylation and cancer. Curr. Opin. Genet. Dev. 9: 171–174.

    Article  CAS  PubMed  Google Scholar 

  • Baeuerle, P. A., and Baltimore, D., 1988, IkB: a specific inhibitor of the NF-kB transcription factor. Science 242: 540–546.

    Article  CAS  PubMed  Google Scholar 

  • Berger, S. L., 1999, Gene activation by histone and factor acetyltransferases. Curr. Opin. Cell Biol 11: 336–341.

    CAS  Google Scholar 

  • Blobel, G. A., 2000, CREB-binding protein and p300: molecular integrators of hematopoietic transcription. Blood 95: 745–755.

    CAS  PubMed  Google Scholar 

  • Boone, E., Vandevoorde, V., De Wilde, G., and Haegeman, G., 1998, Activation of p42/p44 mitogen-activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptor. FEBSLett. 441:275–280.

    Article  CAS  Google Scholar 

  • Chen, D., Ma, H., Hong; H., Koh, S. S., Huang, S. M, Schurter, B. T., Aswad, D. W., and Stallcup, M. R., 1999, Regulation of transcription by a protein methyltransferase. Science 284: 2174–2177.

    Article  CAS  PubMed  Google Scholar 

  • Chen, L. F., Mu, Y., and Greene, W. C, 2002, Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kB. EMBOJ. 21: 6539–6548.

    Article  CAS  Google Scholar 

  • Chinetti, G., Griglio, S., Antonucci, M., Torra, I. P., Delerive, P., Majd, Z., Fruchart, J. C, Chapman, J., Najib, J., and Staels, B., 1998, Activation of proliferator-activated receptors a and y induces apoptosis of human monocyte-derived macrophages. J. Biol. Chem. 273: 25573–25580.

    Article  CAS  PubMed  Google Scholar 

  • Deak, M., Clifton, A. D., Lucocq, L. M., and Alessi, D. R., 1998, Mitogen-and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBOJ. 17:4426–4441.

    Article  CAS  Google Scholar 

  • Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J. C, Tedgui, A., Haegeman, G., and Staels, B., 1999, Peroxisome proliferator-activated receptor a negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kB and AP-1.J. Biol. Chem. 274: 32048–32054.

    Article  CAS  PubMed  Google Scholar 

  • Delerive, P., Gervois, P., Fruchart, J. C, and Staels, B., 2000, Induction of IkBα expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-a activators.J. Biol. Chem.275:36703–36707.

    Article  CAS  PubMed  Google Scholar 

  • Delerive, P., De Bosscher, K., Vanden Berghe, W., Fruchart, J. C, Haegeman, G., and Staels, B., 2002, DNA binding-independent induction of IkBα gene transcription by PPARa.Mol. Endocrinol.16:1029–1039.

    Article  CAS  PubMed  Google Scholar 

  • Deng, W. G., Zhu, Y., and Wu, K. K., 2003, Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-a-induced cyclooxygenase-2 promoter activation.J. Biol. Chem.278:4770–4777.

    Article  CAS  PubMed  Google Scholar 

  • Desvergne, B., and Wahli, W., 1999, Peroxisome proliferator-activated receptors: nuclear control of metabolism.Endocr. Rev.20:649–688.

    Article  CAS  PubMed  Google Scholar 

  • Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., and Wahli, W., 1996, The PPARa-leukotriene B4 pathway to inflammation control.Nature384:39–43.

    Article  CAS  PubMed  Google Scholar 

  • Dixit, V., and Mak, T. W., 2002, NF-kB signaling. Many roads lead to Madrid.Cell111:615–619.

    Article  CAS  PubMed  Google Scholar 

  • El Kharroubi, A., Piras, G., Zensen, R., and Martin, M. A., 1998, Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.Mol. Cell. Biol.18:2535–2544.

    PubMed  Google Scholar 

  • Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., and Collins, T., 1997, CREB- binding protein/p300 are transcriptional coactivators of p65.Proc. Natl. Acad. Sci. USA94:2927–2932.

    Article  CAS  PubMed  Google Scholar 

  • Ghosh, S., and Karin, M., 2002, Missing pieces in the NF-kB puzzle.Cell109:S81–96.

    Article  CAS  PubMed  Google Scholar 

  • Giles, R. H., Peters, D. J., and Breuning, M. H., 1998, Conjunction dysfunction: CBP/p300 in human disease.Trends Genet.14:178–183.

    Article  CAS  PubMed  Google Scholar 

  • Gilmore, T. D., 1999, The Rel/NF-KB signal transduction pathway: introduction.Oncogene18:6842–6844.

    Article  CAS  PubMed  Google Scholar 

  • Glass, C. K., and Rosenfeld, M. G., 2000, The coregulator exchange in transcriptional functions of nuclear receptors.Genes Dev.14:121–141.

    CAS  PubMed  Google Scholar 

  • Gregory, P. D., and Horz, W., 1998, Chromatin and transcription. How transcription factors battle with a repressive chromatin environment.Eur. J. Biochem.251:9–18.

    Article  CAS  PubMed  Google Scholar 

  • Gu, W., and Roeder, R. G., 1997, Activation of p53 sequence-specific DNA binding by acetyl-ation of the p53 C-terminal domain.Cell90:595–606.

    Article  CAS  PubMed  Google Scholar 

  • Hampsey, M., and Reinberg, D., 1999, RNA polymerase II as a control panel for multiple coactivator complexes. Curr. Opin. Genet. Dev.9:132–139.

    Article  CAS  PubMed  Google Scholar 

  • Heyninck, K., De Valck, D., Vanden Berghe, W., Van Criekinge, W., Contreras, R., Fiers, W., Haegeman, G., and Beyaert, R., 1999, The zinc finger protein A20 inhibits TNF-induced NF- KB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-KB-inhibiting protein ABIN.J. Cell Biol.145:1471–1482.

    Article  CAS  PubMed  Google Scholar 

  • Holloway, A. F., Rao, S., Chen, X., and Shannon, M. F., 2003, Changes in chromatin accessibility across the GM-CSF promoter upon T cell activation are dependent on nuclear factor kB proteins.J. Exp. Med.197:413–423.

    Article  CAS  PubMed  Google Scholar 

  • Hong, S. H., Wong, C. W., and Privalsky, M. L., 1998, Signaling by tyrosine kinases negatively regulates the interaction between transcription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressorMol. Endocrinol. 12:1161–1171.

    Article  CAS  PubMed  Google Scholar 

  • Huang, T. T., Kudo, N., Yoshida, M, and Miyamoto, S., 2000, A nuclear export signal in the N- terminal regulatory domain of IkBoc controls cytoplasmic localization of inactive NF-KB/IicBa complexes.Proc. Nad. Acad. Sci. USA97:1014–1019.

    Article  CAS  Google Scholar 

  • Dceda, K., Steger, D. J., Eberharter, A., and Workman, J. L., 1999, Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes Mol. Cell. Biol. 19:855–863.

    Google Scholar 

  • Israel, A., 2000, The IKK complex: an integrator of all signals that activate NF-kB?Trends Cell Biol.10:129–133.

    Article  CAS  PubMed  Google Scholar 

  • Ito, C. Y., Kazantsev, A. G., and Baldwin, A. S., 1994, Three NF-kB sites in the IkB-o, promoter are required for induction of gene expression by TNF a.Nucleic Acids Res.22: 3787–3792.

    Article  CAS  PubMed  Google Scholar 

  • Jacobson, S., and Pillus, L., 1999, Modifying chromatin and concepts of cancer.Curr. Opin. Genet. Dev.9:175–184.

    Article  CAS  PubMed  Google Scholar 

  • Delerive, P., Gervois, P., Fruchart, J. C, and Staels, B., 2000, Induction of IkBα expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-a activators.J. Biol. Chem.275:36703–36707.

    Article  CAS  PubMed  Google Scholar 

  • Delerive, P., De Bosscher, K., Vanden Berghe, W., Fruchart, J. C, Haegeman, G., and Staels, B., 2002, DNA binding-independent induction of IkBα gene transcription by PPARa.Mol. Endocrinol.16:1029–1039.

    Article  CAS  PubMed  Google Scholar 

  • Deng, W. G., Zhu, Y., and Wu, K. K., 2003, Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-a-induced cyclooxygenase-2 promoter activation.J. Biol. Chem.278:4770–4777.

    Article  CAS  PubMed  Google Scholar 

  • Desvergne, B., and Wahli, W., 1999, Peroxisome proliferator-activated receptors: nuclear control of metabolism.Endocr. Rev.20:649–688.

    Article  CAS  PubMed  Google Scholar 

  • Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., and Wahli, W., 1996, The PPARa-leukotriene B4 pathway to inflammation control.Nature384:39–43.

    Article  CAS  PubMed  Google Scholar 

  • Dixit, V., and Mak, T. W., 2002, NF-kB signaling. Many roads lead to Madrid.Cell111:615–619.

    Article  CAS  PubMed  Google Scholar 

  • El Kharroubi, A., Piras, G., Zensen, R., and Martin, M. A., 1998, Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.Mol. Cell. Biol.18:2535–2544.

    PubMed  Google Scholar 

  • Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., and Collins, T., 1997, CREB- binding protein/p300 are transcriptional coactivators of p65.Proc. Natl. Acad. Sci. USA94:2927–2932.

    Article  CAS  PubMed  Google Scholar 

  • Ghosh, S., and Karin, M., 2002, Missing pieces in the NF-kB puzzle.Cell109:S81–96.

    Article  CAS  PubMed  Google Scholar 

  • Giles, R. H., Peters, D. J., and Breuning, M. H., 1998, Conjunction dysfunction: CBP/p300 in human disease.Trends Genet.14:178–183.

    Article  CAS  PubMed  Google Scholar 

  • Gilmore, T. D., 1999, The Rel/NF-KB signal transduction pathway: introduction.Oncogene18:6842–6844.

    Article  CAS  PubMed  Google Scholar 

  • Glass, C. K., and Rosenfeld, M. G., 2000, The coregulator exchange in transcriptional functions of nuclear receptors.Genes Dev.14:121–141.

    CAS  PubMed  Google Scholar 

  • Gregory, P. D., and Horz, W., 1998, Chromatin and transcription. How transcription factors battle with a repressive chromatin environment.Eur. J. Biochem.251:9–18.

    Article  CAS  PubMed  Google Scholar 

  • Gu, W., and Roeder, R. G., 1997, Activation of p53 sequence-specific DNA binding by acetyl-ation of the p53 C-terminal domain.Cell90:595–606.

    Article  CAS  PubMed  Google Scholar 

  • Hampsey, M., and Reinberg, D., 1999, RNA polymerase II as a control panel for multiple coactivator complexes. Curr. Opin. Genet. Dev.9:132–139.

    Article  CAS  PubMed  Google Scholar 

  • Heyninck, K., De Valck, D., Vanden Berghe, W., Van Criekinge, W., Contreras, R., Fiers, W., Haegeman, G., and Beyaert, R., 1999, The zinc finger protein A20 inhibits TNF-induced NF- KB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-KB-inhibiting protein ABIN.J. Cell Biol.145:1471–1482.

    Article  CAS  PubMed  Google Scholar 

  • Holloway, A. F., Rao, S., Chen, X., and Shannon, M. F., 2003, Changes in chromatin accessibility across the GM-CSF promoter upon T cell activation are dependent on nuclear factor kB proteins.J. Exp. Med.197:413–423.

    Article  CAS  PubMed  Google Scholar 

  • Hong, S. H., Wong, C. W., and Privalsky, M. L., 1998, Signaling by tyrosine kinases negatively regulates the interaction between transcription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressorMol. Endocrinol. 12:1161–1171.

    Article  CAS  PubMed  Google Scholar 

  • Huang, T. T., Kudo, N., Yoshida, M, and Miyamoto, S., 2000, A nuclear export signal in the N- terminal regulatory domain of IkBoc controls cytoplasmic localization of inactive NF-KB/IicBa complexes.Proc. Nad. Acad. Sci. USA97:1014–1019.

    Article  CAS  Google Scholar 

  • Dceda, K., Steger, D. J., Eberharter, A., and Workman, J. L., 1999, Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes Mol. Cell. Biol. 19:855–863.

    Google Scholar 

  • Israel, A., 2000, The IKK complex: an integrator of all signals that activate NF-kB?Trends Cell Biol.10:129–133.

    Article  CAS  PubMed  Google Scholar 

  • Ito, C. Y., Kazantsev, A. G., and Baldwin, A. S., 1994, Three NF-kB sites in the IkB-o, promoter are required for induction of gene expression by TNF a.Nucleic Acids Res.22: 3787–3792.

    Article  CAS  PubMed  Google Scholar 

  • Jacobson, S., and Pillus, L., 1999, Modifying chromatin and concepts of cancer.Curr. Opin. Genet. Dev.9:175–184.

    Article  CAS  PubMed  Google Scholar 

  • Jin, Y., Wang, Y., Walker, D. L., Dong, H., Conley, C, Johansen, J., and Johansen, K. M., 1999, JIL-1: a novel chromosomal tandem kinase implicated in transcriptional regulation in Drosophila. Mol. Cell 4:129–135.

    Article  CAS  PubMed  Google Scholar 

  • Johnson, C., Van Antwerp, D., and Hope, T. J., 1999, An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκBα. EMBOJ. 18: 6682–6693.

    Article  CAS  Google Scholar 

  • Kadonaga, J. T., 1998, Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines. Cell 92: 307–313.

    Article  CAS  PubMed  Google Scholar 

  • Kieman, R., Bres, V., Ng, R. W., Coudait, M. P., El Messaoudi, S., Sardet, C, Jin, D. Y., Emiliani, S., and Benkirane, M., 2003, Post-activation turn-off of NF-κB-dependent transcription is regulated by acetylation of p65. J. Biol. Chem. 278:2758–2766.

    Article  CAS  Google Scholar 

  • Ko, L., Cardona, G. R., and Chin, W. W., 2000, Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc. Nad. Acad. Sci. USA 97: 6212–6217.

    Article  CAS  Google Scholar 

  • Kornberg, R. D., and Lorch, Y., 1999, Chromatin-modifying and -remodeling complexes. Curr. Opin. Genet. Dev. 9: 148–151.

    Article  CAS  PubMed  Google Scholar 

  • Korzus, E., Torchia, J., Rose, D. W., Xu, L., Kurokawa, R., Mclnemey, E. M., Mullen, T. M., Glass, C. K., and Rosenfeld, M. G., 1998, Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279: 703–707.

    Article  CAS  PubMed  Google Scholar 

  • Kouzarides, T., 1999, Histone acetylases and deacetylases in cell proliferation. Curr. Opin. Genet. Dev. 9:40–48.

    Article  CAS  PubMed  Google Scholar 

  • Kouzarides, T., 2000, Acetylation: a regulatory modification to rival phosphorylation? EMBO J. 19:1176–1179.

    Article  CAS  PubMed  Google Scholar 

  • Krey, G., Mahfoudi, A., and Wahli, W., 1995, Functional interactions of peroxisome proliferator-activated receptor, retinoid-X receptor, and Spl in the transcriptional regulation of the acyl-coenzyme-A oxidase promoter. Mol. Endocrinol. 9:219–231.

    Article  CAS  PubMed  Google Scholar 

  • Kuo, M. H., and Allis, C. D., 1998, Roles of histone acetyltransferases and deacetylases in gene regulation. BioEssays 20: 615–626.

    Article  CAS  PubMed  Google Scholar 

  • Kurokawa, R., Kalafus, D., Ogliastro, M. H., Kioussi, C, Xu, L., Torchia, J., Rosenfeld, M. G., and Glass, C. K., 1998, Differential use of CREB binding protein-coactivator complexes. Science 279: 700–703.

    Article  CAS  PubMed  Google Scholar 

  • Le Bail, O., Schmidt-Ullrich, R., and Israel, A., 1993, Promoter analysis of the gene encoding the IκB-α/MAD3 inhibitor of κB: positive regulation by members of the rel/NF-κB family. EMBOJ. 12: 5043–5049.

    Google Scholar 

  • Li, Q., and Verma, I. M, 2002, NF-κB regulation in the immune system. Nat. Rev. Immuhol. 2:725–734.

    Article  CAS  Google Scholar 

  • Lomvardas, S., and Thanos, D., 2002, Modifying gene expression programs by altering core promoter chromatin architecture. Cell 110:261–271.

    Article  CAS  PubMed  Google Scholar 

  • Malek, S., Chen, Y., Huxford, T., and Ghosh, G., 2001, IκBα, but not IκBα, functions as a classical cytoplasmic inhibitor of NF-κB dimers by masking both NF-κB nuclear localization sequences in resting cells. J. Biol Chem. 276:45225–45235.

    Article  CAS  PubMed  Google Scholar 

  • Marx, N., Sukhova, G. K., Collins, T., Libby, P., and Plutzky, J., 1999, PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 99: 3125–3131.

    Article  CAS  PubMed  Google Scholar 

  • Mercurio, F., and Manning, A. M., 1999, Multiple signals converging on NF-κB. Curr. Opin. Cell Biol 11: 226–232.

    Article  CAS  PubMed  Google Scholar 

  • Merika, M., Williams, A. J., Chen, G., Collins, T., and Thanos, D., 1998, Recruitment of CBP/p300 by the IFN β enhanceosome is required for synergistic activation of transcription. Mol Cell 1:277–287.

    Article  CAS  PubMed  Google Scholar 

  • Merika, M., and Thanos, D., 2001, Enhanceosomes. Curr. Opin. Genet. Dev. 11:205–208.

    Article  CAS  PubMed  Google Scholar 

  • Munshi, N., Merika, M., Yie, J., Senger, K., Chen, G., and Thanos, D., 1998, Acetylation of HMG I(Y) by CBP turns off IFN β expression by disrupting the enhanceosome. Mol Cell 2:457–467.

    Article  CAS  PubMed  Google Scholar 

  • Muraoka, M., Konishi, M., Kikuchi-Yanoshita, R., Tanaka, K., Shitara, N., Chong, J. M., Iwama, T., and Miyaki, M., 1996, p300 gene alterations in colorectal and gastric carcinomas. Oncogene 12:1565–1569.

    CAS  PubMed  Google Scholar 

  • Owen, G. I., Richer, J. K., Tung, L., Takimoto, G., and Horwitz, K. B., 1998, Progesterone regulates transcription of the p21(WAFl) cyclin-dependent kinase inhibitor gene through Spl and CBP/p300. J. Biol Chem. 273: 10696–10701.

    Article  CAS  PubMed  Google Scholar 

  • Pahl, H. L., 1999, Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18: 6853–6866.

    Article  CAS  PubMed  Google Scholar 

  • Parekh, B. S., and Maniatis, T., 1999, Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-P promoterMol Cell 3: 125–129.

    Article  CAS  PubMed  Google Scholar 

  • Perissi, V., Dasen, J. S., Kurokawa, R., Wang, Z., Korzus, E., Rose, D. W., Glass, C. K., and Rosenfeld, M. G., 1999, Factor-specific modulation of CREB-binding protein acetyltransferase activity.Proc. Natl Acad. Sci. USA 96: 3652–3657.

    Article  CAS  PubMed  Google Scholar 

  • Perkins, N. D., Felzien, L. K., Betts, J. C, Leung, K., Beach, D. H., and Nabel, G. J., 1997, Regulation of NF-kB by cyclin-dependent kinases associated with the p300 coactivator.Science 275: 523–527.

    Article  CAS  PubMed  Google Scholar 

  • Peters, R. T., Liao, S. M., and Maniatis, T., 2000, IKKe is part of a novel PMA-inducible IkB kinase complex.Mol Cell 5: 513–522.

    Article  CAS  PubMed  Google Scholar 

  • Pierrat, B., Correia, J. S., Mary, J. L., Tomas-Zuber, M., and Lesslauer, W., 1998, RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38a mitogen-activated protein kinase (p38aMAPK)J. Biol. Chem 273: 29661–29671.

    Article  CAS  PubMed  Google Scholar 

  • Pollard, K. J., and Peterson, C. L., 1998, Chromatin remodeling: a marriage between two families?BioEssays 20:771–780.

    Article  CAS  PubMed  Google Scholar 

  • Poynter, M. E., and Daynes, R. A., 1998, Peroxisome proliferator-activated receptor a activation modulates cellular redox status, represses nuclear factor-KB signaling, and reduces inflammatory cytokine production in aging.J. Biol. Chem 273:32833–32841.

    Article  CAS  PubMed  Google Scholar 

  • Qi, C, Zhu, Y., Pan, J., Yeldandi, A. V., Rao, M. S., Maeda, N., Subbarao, V., Pulikuri, S., Hashimoto, T., and Reddy, J. K., 1999, Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor a-regulated gene expression.Proc. Natl. Acad. Sci. USA 96: 1585–1590.

    Article  CAS  PubMed  Google Scholar 

  • Richmond, A., 2002, NF-kB, chemokine gene transcription and tumour growth.Nat. Rev. Immunol 2: 664–674.

    Article  CAS  PubMed  Google Scholar 

  • Ricote, M, Li, A. C, Willson, T. M., Kelly, C. J., and Glass, C. K., 1998, The peroxisome proliferator-activated receptor-y is a negative regulator of macrophage activation.Nature 391:79–82.

    Article  CAS  PubMed  Google Scholar 

  • Rothwarf, D. M., and Karin, M., 1999, The NF-kB activation pathway: a paradigm in information transfer from membrane to nucleusSet STKE 1999: RE1

    CAS  Google Scholar 

  • Saccani, S., Pantano, S., and Natoli, G., 2002, p38 Dependent marking of inflammatory genes for increased NF-kB recruitmentNat. Immunol 3: 69–75.

    Article  CAS  PubMed  Google Scholar 

  • Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., and Appella, E., 1998, DNA damage activates p53 through a phosphorylation-acetylation cascade.Genes Dev 12:2831–2841.

    Article  CAS  PubMed  Google Scholar 

  • Saville, B., Wormke, M., Wang, F., Nguyen, T., Enmark, E., Kuiper, G., Gustafsson, J. A., and Safe, S., 2000, Ligand-, cell-, and estrogen receptor subtype (a/p)-dependent activation at GC- rich (Spl) promoter elements.J. Biol. Chem 275: 5379–5387.

    Article  CAS  PubMed  Google Scholar 

  • Sheppard, K. A., Rose, D. W., Haque, Z. K., Kurokawa, R., Mclnemey, E., Westin, S., Thanos, D., Rosenfeld, M. G., Glass, C. K., and Collins, T., 1999, Transcriptional activation by NF-kB requires multiple coactivators.Mol. Cell. Biol 19: 6367–6378.

    CAS  PubMed  Google Scholar 

  • Sheridan, P. L., Mayall, T. P., Verdin, E., and Jones, K. A., 1997, Histone acetyltransferases regulate HIV-1 enhancer activity in vitroGenes Dev 11: 3327–3340.

    Article  CAS  PubMed  Google Scholar 

  • Smale, S. T., and Fisher, A. G., 2002, Chromatin structure and gene regulation in the immune system.Annu. Rev. Immunol 20: 427–462.

    Article  CAS  PubMed  Google Scholar 

  • Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E., and Fruchart, J. C, 1998a, Mechanism of action of fibrates on lipid and lipoprotein metabolism.Circulation 98: 2088–2093.

    Article  CAS  Google Scholar 

  • Staels, B., Koenig, W., Habib, A., Merval, R., Lebret, M., Torra, I. P., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J. C, Najib, J., Maclouf, J., and Tedgui, A., 1998b, Activation of human aortic smooth-muscle cells is inhibited by PPARa but not by PPARy activators.Nature 393: 790–793.

    Article  CAS  Google Scholar 

  • Strahl, B. D., and Allis, C. D., 2000, The language of covalent histone modifications.Nature 403:41–45.

    Article  CAS  PubMed  Google Scholar 

  • Tarn, W. F., and Sen, R., 2001, IkB family members function by different mechanisms.J. Biol. Chem 276: 7701–7704.

    Article  CAS  PubMed  Google Scholar 

  • Thomson, S., Clayton, A. L., Hazzalin, C. A., Rose, S., Barratt, M. J., and Mahadevan, L. C, 1999, The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase.EMBO J. 18,4779–4793.

    Article  CAS  PubMed  Google Scholar 

  • Tomas–Zuber, M., Mary, J. L., and Lesslauer, W., 2000, Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor.J. Biol. Chem.275,23549–23558.

    Article  CAS  PubMed  Google Scholar 

  • Torchia, J., Rose, D. W., Inostroza, J., Kamei, Y., Westin, S., Glass, C. K., and Rosenfeld, M. G., 1997, The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature387,677–684.

    Article  CAS  PubMed  Google Scholar 

  • Torchia, J., Glass, C, and Rosenfeld, M. G., 1998, Co-activators and co-repressors in the integration of transcriptional responses.Curr. Opin. Cell Biol10, 373–383.

    Article  CAS  PubMed  Google Scholar 

  • Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., and Green, S., 1992, The mouse peroxisome proliferator activated receptor recognizes a response element in the 5’ flanking sequence of the rat acyl CoA oxidase gene.EMBO J.11,433–439.

    CAS  PubMed  Google Scholar 

  • Utley, R. T., Ikeda, K., Grant, P. A., Cote, J., Steger, D. J., Eberharter, A., John, S., and Workman, J. L., 1998, Transcriptional activators direct histone acetyltransferase complexes to nucleosomes.Nature394,498–502.

    Article  CAS  PubMed  Google Scholar 

  • Vanden Berghe, W., Plaisance, S., Boone, E., De Bosscher, K., Schmitz, M. L., Fiers, W., and Haegeman, G., 1998, p38 and extracellular signal–regulated kinase mitogen–activated protein kinase pathways are required for nuclear factor–KB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem.273, 3285–3290

    Article  CAS  PubMed  Google Scholar 

  • Vanden Berghe, W., De Bosscher, K., Boone, E., Plaisance, S., and Haegeman, G., 1999, The nuclear factor-KB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.J. Biol. Chem.274, 32091–32098.

    Article  CAS  PubMed  Google Scholar 

  • Vanden Berghe, W., Vermeulen, L., De Wilde, G., De Bosscher, K., Boone, E., and Haegeman, G., 2000, Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.Biochem. Pharmacol60,1185–1195.

    Article  CAS  PubMed  Google Scholar 

  • Vanden Berghe, W., De Bosscher, K., Vermeulen, L., De Wilde, G., and Haegeman, G., 2002, Induction and repression of NF-KB-driven inflammatory genes. Ernst Schering Res. Found. Workshop40,233 –278

    CAS  PubMed  Google Scholar 

  • Vandevoorde, V., Haegeman, G., and Fiers, W., 1997, Induced expression of trimerized intra-cellular domains of the human tumor necrosis factor (TNF) p55 receptor elicits TNF effects.J. Cell Biol137, 1627–1638.

    Article  CAS  PubMed  Google Scholar 

  • Van Lint, C, Emiliani, S., Ott, M., and Verdin, E., 1996, Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation.EMBOJ.15,1112–1120.

    Google Scholar 

  • Vermeulen, L., De Wilde, G., Notebaert, S., Vanden Berghe, W., and Haegeman, G., 2002, Regulation of the transcriptional activity of the nuclear factor-KB p65 subunit. Biochem. Pharmacol64, 963–970.

    Article  CAS  PubMed  Google Scholar 

  • Vermeulen, L., De Wilde, G., Van Damme, P., Vanden Berghe, W., and Haegeman, G., 2003, Transcriptional activation of the NF-kB p65 subunit by mitogen-and stress-activated protein kinase-1 (MSK1). EMBO J.22,1313–1324.

    Article  CAS  PubMed  Google Scholar 

  • Wajant, H., Pfizenmaier, K., and Scheurich, P., 2003, Tumor necrosis factor signaling. Cell Death Differ. 10,45–65.

    Article  CAS  PubMed  Google Scholar 

  • Weinmann, A. S., Plevy, S. E., and Smale, S. T., 1999, Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription.Immunity11, 665–675.

    Article  CAS  PubMed  Google Scholar 

  • Wajant, H., Pfizenmaier, K., and Scheurich, P., 2003, Tumor necrosis factor signaling. Cell Death Differ. 10,45–65.

    Article  CAS  PubMed  Google Scholar 

  • Weinmann, A. S., Mitchell, D. M, Sanjabi, S., Bradley, M. N., Hoffmann, A., Liou, H. C, and Smale, S. T., 2001, Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event. Nat. Immunol. 2, 51–57.

    Article  CAS  PubMed  Google Scholar 

  • Wesselborg, S., Bauer, M. K., Vogt, M., Schmitz, M. L., and Schulze-Osthoff, K., 1997, Activation of transcription factor NF-kB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways.J. Biol Chem.272, 12422–12429.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, S. Q., Kovalenko, A., Cantarella, G., and Wallach, D., 2000, Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKy) upon receptor stimulation.Immunity 12: 301–311.

    Article  CAS  PubMed  Google Scholar 

  • Zhong, H., May, M. J., Jimi, E., and Ghosh, S., 2002, The phosphorylation status of nuclear NF- kB determines its association with CBP/p300 or HDAC-1.Mol Cell 9: 625–636.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Biology, University of Gent, K.L. Ledeganckstraat 35, Gent, 9000, Belgium

    Wim Vanden Berghe, Linda Vermeulen, Philippe Delerive, Karolien De Bosscher & Guy Haegeman

  2. Institut National de la Santé et de la Recherche Médicale U545, Département d’Athérosclérose, Institut Pasteur, 59019, Lille, France

    Philippe Delerive & Bart Staels

Authors
  1. Wim Vanden Berghe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Linda Vermeulen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Philippe Delerive
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Karolien De Bosscher
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Bart Staels
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Guy Haegeman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Ghent University, Ghent, Belgium

    Frank Roels  & Sylvia De Bie  & 

  2. K.U. Leuven, Leuven, Belgium

    Myriam Baes

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this paper

Cite this paper

Vanden Berghe, W., Vermeulen, L., Delerive, P., De Bosscher, K., Staels, B., Haegeman, G. (2003). A Paradigm for Gene Regulation: Inflammation, NF-κB and PPAR. In: Roels, F., Baes, M., De Bie, S. (eds) Peroxisomal Disorders and Regulation of Genes. Advances in Experimental Medicine and Biology, vol 544. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9072-3_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-9072-3_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4782-8

  • Online ISBN: 978-1-4419-9072-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation