Abstract
Over the past 20 years, we have collaborated with several laboratories in using mathematical modeling to describe and quantitate whole-body Vitamin A Metabolism in the rat. Steady state models have been developed for animals at different levels of vitamin A status (Green et al., 1985; Lewis et al., 1990; Green and Green, 1994a; Kelley and Green, 1998) and in response to other variables (Kelley et al., 1998; Jang et al., 2000; Kelley et al., 2000). Limited experimental and mathematical evidence (Green and Green, 1994b; Novotny et al., 1995; v Reinersdorff et al., 1998) suggests that there are many similarities in Vitamin A Metabolism between rats and humans. As discussed at the 5th Conference on Mathematical Modeling in Experimental Nutrition in 1994 (Green and Green, 1996), modeling studies have uniquely contributed to current understanding of whole-body Vitamin A Metabolism. In particular, interpretation of kinetic data has revealed previously unrecognized complexities in vitamin A dynamics that facilitate homeostatic control of plasma (and probably tissue) vitamin A levels.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adams, W.R., Smith, J.E., and Green, M.H., 1995, Effects of N-(4-hydroxyphenyl)retinamide on Vitamin A Metabolism in rats, Proc. Soc. Exp. Biol. Med. 208:178–185.
Berman, M., and Weiss, M.F., 1978, SAAM Manual, DHEW Publ. #78–180, U.S. Government Printing Office, Washington, DC.
Blaner, W.S., and Olson, J.A., 1994, Retinol and retinoic acid metabolism, in: The Retinoids: Biology, Chemistry, and Medicine, 2nd edn., M.B. Sporn, A.B. Roberts, and D.S. Goodman, eds., Raven Press, New York.
Blomhoff, R., Green, M.H., Green, J.B., Berg, T., and Norum, K.R., 1991, Vitamin A Metabolism: new perspectives on absorption, transport, and storage, Physiol Rev. 71:951–990.
Green, M.H., Uhl, L., and Green, J.B., 1985, A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores, J. Lipid Res. 26:806–818.
Green, M.H., and Green, J.B., 1990a, Experimental and kinetic methods for studying vitamin A dynamics in vivo, Meth. Enzymol 190:304–317.
Green, M.H., and Green, J.B., 1990b, The application of compartmental analysis to research in nutrition, Ann. Rev. Nutr. 10:41–61.
Green, M.H., and Green, J.B., 1994a, Vitamin A intake and status influence retinol balance, utilization and dynamics in rats, J. Nutr. 124:2477–2485.
Green, M.H., and Green, J.B., 1994b, Dynamics and control of plasma retinol, in: Vitamin A in Health and Disease, R. Blomhoff, ed., Marcel Dekker, New York.
Green, M.H., and Green, J.B., 1996, Quantitative and conceptual contributions of mathematical modeling to current views on Vitamin A Metabolism, biochemistry, and nutrition, Adv. Food Nutr. Res. 40:3–24.
Jang, J.-T., Green, J.B., Beard, J.L., and Green, M.H., 2000, Kinetic analysis shows that iron deficiency decreases liver vitamin A mobilization in rats, J. Nutr. 130:1291–1296.
Kelley, S.K., and Green, M.H., 1998, Plasma retinol is a major determinant of vitamin A utilization in rats, J. Nutr. 128:1767–1773.
Kelley, S.K., Nilsson, C.B., Green, M.H., Green, J.B., and Håkansson, H., 1998, Use of model-based compartmental analysis to study effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A kinetics in rats, Toxicol. Sci. 44:1– 13.
Kelley, S.K., Nilsson, C.B., Green, M.H., Green, J.B., and Håkansson, H., 2000, Mobilization of vitamin A stores in rats after administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin: a kinetic analysis, Toxicol. Sci. 55:478–484.
Landaw, E.M., and DiStefano III, J.J., 1984, Multiexponential, multicompartmental and noncompartmental modeling. II. Data analysis and statistical considerations, Am. J. Physiol. 246:R665–R677.
Lewis, K.C., Green, M.H., Green, J.B., and Zech, L.A., 1990, Retinol metabolism in rats with low vitamin A status: a multicompartmental model, J. Lipid Res. 31:1535–1548.
Novotny, J.A., Dueker, S.R., Zech, L.A., and Clifford, A.J., 1995, Compartmental analysis of the dynamics of Rcarotene metabolism in an adult volunteer, J. Lipid Res. 36.1825–1838.
v Reinersdorff, D., Green, M.H., and Green, J.B., 1998, Development of a compartmental model describing the dynamics of Vitamin A Metabolism in men, in: Mathematical Modeling in Experimental Nutrition, A. J. Clifford and H.-J. Miiller, eds., Plenum Press, New York.
Wastney, M.E., Patterson, B.H., Linares, O.A., Greif, P.C., and Boston, R.C., 1999, WinSAAM, in: Investigating Biological Systems Using Modeling: Strategies and Software, Academic Press, San Diego.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Green, M.H., Green, J.B. (2003). The Use of Model-Based Compartmental Analysis to Study Vitamin A Metabolism in a Non-Steady State. In: Novotny, J.A., Green, M.H., Boston, R.C. (eds) Mathematical Modeling in Nutrition and the Health Sciences. Advances in Experimental Medicine and Biology, vol 537. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9019-8_11
Download citation
DOI: https://doi.org/10.1007/978-1-4419-9019-8_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4759-0
Online ISBN: 978-1-4419-9019-8
eBook Packages: Springer Book Archive