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Binding and Extraction of Pertechnetate and Perrhenate by Azacages

  • Chapter
Fundamentals and Applications of Anion Separations

Abstract

The design and synthesis of anion receptors of technical and biochemical significance is receiving more and more attention.1–8Currently, effective binding and selective phase transfer of the oxoanions pertechnetate and perrhenate is of considerable interest from different point of view. Due to its long half-life and environmental mobility, the radioactive pertechnetate is one of the most hazardous contaminants. In this context, effective and selective separation processes are of utmost importance.9–12 On the other hand, there are some emerging possibilities for the application of the radiochemically active oxoanions pertechnetate and perrhenate in nuclear medicine.13,14 The most commonly used isotope in diagnostic nuclear medicine 99mTc is readily available from a 99Mo/99mTc generator system.15–19 Likewise, the β-emitting 188Re - discussed as one of the most interesting radionuclides for specific therapeutic applications — is conveniently produced by a 188W/188Re generator.20–22 In both cases the radionuclides are available as oxoanions in isotonic solut ion, and it appears highly desirable to directly complex 99mTcO− 4 and 188ReO− 4 as they exist in the generator eluate itself. But, the binding of such large, lowly charged anions is a difficult venture. The enthalpic contribution for complexation is rather small. Hence, host compounds being capable to encapsulate these oxoanions are of great interest.

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Authors and Affiliations

  1. Forschungszentrum Rossendorf, Institut für Bioanorganische und Radiopharmazeutische Chemie, PF 510119,01314, Dresden, Germany

    Holger Stephan, Hartmut Spies, Bernd Johannsen & Kathrin Wichmann

  2. Institut für Anorganische Chemie, Technische Universität Dresden, 01062, Dresden, Germany

    Karsten Gloe & GUnter Reck

  3. Bundesanstalt für Materialforschung und -prüfung, Richard-Willstätter-Strasse 11, 12489, Berlin, Germany

    Werner Kraus & DillipK. Chand

  4. Department of Chemistry, Indian Institute of Technology, Kanpur, 208016, India

    Parimal K. Bharadwa & Ute Müller

  5. Universität Bonn, Kekulé-Institut für OrganischeChemie und Biochemie, Gerhard-Domagk-Strasse 1, 53121, Bonn, Germany

    WalterM. Müller & Fritz Vögtle

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Editors and Affiliations

  1. Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    Bruce A. Moyer

  2. Osram Sylvania, Towanda, Pennsylvania, USA

    Raj P. Singh

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Stephan, H. et al. (2004). Binding and Extraction of Pertechnetate and Perrhenate by Azacages. In: Moyer, B.A., Singh, R.P. (eds) Fundamentals and Applications of Anion Separations. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8973-4_10

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  • DOI: https://doi.org/10.1007/978-1-4419-8973-4_10

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