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Cathepsins B1 and B2 of Trichobilharzia SPP., Bird Schistosomes Causing Cercarial Dermatitis

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Cysteine Proteases of Pathogenic Organisms

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 712))

Abstract

Trichobilharzia regenti and T. szidati are schistosomes that infect birds. although T. regenti/T. szidati can only complete their life cycle in specific bird hosts (waterfowl), their larvae—cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts (e.g., mouse, man). Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host and include cysteine peptidases such as cathepsins B1 and B2. These enzymes are indispensable bio-catalysts in a number of basal biological processes and host-parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes (T. regenti, T. szidati) and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines.

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Authors and Affiliations

  1. Department of Parasitology, Faculty of Science, Charles University in Prague, Czech Republic

    Martin Kašný, Libor Mikeš, Kateřina Dolečková, Vladimír Hampl & Petr Horák

  2. Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Budějovice, Czech Republic

    Jan Dvořák

  3. Department of Cell Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic

    Marian Novotný

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  1. Martin Kašný
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  2. Libor Mikeš
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  3. Kateřina Dolečková
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Editors and Affiliations

  1. Infection, Immunity and Innovation (i3) Institute, University of Technology Sydney, Ultimo, Sydney, Australia

    Mark W. Robinson PhD

  2. Institute of Parasitology, McGill University, McDonald Campus, St. Anne de Bellevue, Quebec, Canada

    John P. Dalton PhD

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Kašný, M. et al. (2011). Cathepsins B1 and B2 of Trichobilharzia SPP., Bird Schistosomes Causing Cercarial Dermatitis. In: Robinson, M.W., Dalton, J.P. (eds) Cysteine Proteases of Pathogenic Organisms. Advances in Experimental Medicine and Biology, vol 712. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8414-2_9

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