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Modeling Tumor Growth in Oncology

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Pharmacokinetics in Drug Development

Abstract

In cancer drug development, measurement of tumor growth is necessary for preclinical assessment of anticancer activity and clinical assessment of efficacy. This chapter reviews mathematical models of preclinical and clinical tumor growth. Issues and models with regards to mouse xenograft data will be highlighted.

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-1-4419-7937-7_14

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-1-4419-7937-7_14

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Notes

  1. 1.

    Houk et al. discussed this model in another chapter in this book.

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Authors and Affiliations

  1. Clinical Pharmacology, Modeling, and Simulation, GlaxoSmithKline, 5 Moore Drive, 17.2259, Research Triangle Park, Durham, NC, 27709, USA

    Peter L. Bonate

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Correspondence to Peter L. Bonate .

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  1. , Pharmacokinetics, Modeling, and Simulati, Astellas Pharma, Parkway North 3, Deerfield, 60015, Illinois, USA

    Peter L. Bonate

  2. Institutes for Biomedical Research, Translational Sciences, Novartis, Health Plaza 1, East Hanover, 07936, New Jersey, USA

    Danny R. Howard

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Bonate, P.L. (2011). Modeling Tumor Growth in Oncology. In: Bonate, P., Howard, D. (eds) Pharmacokinetics in Drug Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7937-7_1

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