Abstract
Dendritic cells (DC) are critically required for the host response to antigen (Ag) [1, 2]. Upon exposure to antigen, DC take up Ag within the peripheral tissues and subsequently migrate in response to chemokine gradients into the lymphatics [3]. During this initial exposure to Ag, DC become activated by the sensing of microbe-associated molecular patterns (MAMPs) and consequently upregulate co-stimulatory molecules such as B7.1 and B7.2 so that they may optimally prime Ag-specific CD4+ T cells [4–6]. DC leave the tissue and enter the lymphatics where they journey to the inflamed draining lymph node (LN) [7, 8]. Upon entry into the LN via the subcapsular sinus, DC “find” rare Ag-specific CD4+ T cells by taking advantage of the intricate organization of the LN tissue itself [9]. Once DC encounter Ag-specific T cells, the T cells become activated to proliferate. These activated T cells also concurrently provide signals back to the Ag-bearing DC in a process that has been termed DC licensing. Licensed DC can then cross-prime a CD8+ T-cell response so that pathogen may be cleared. The nature of these helper T cell-derived signals and their impact on the Ag-bearing DC remain poorly elucidated.
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The authors wish to acknowledge the support of the Canadian Institutes of Health Research (CIHR/IRSC) for a doctoral award to LSD and an operating grant to JLG (MOP #67157).
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Summers deLuca, L., Gommerman, J.L. (2011). The Lymphotoxin Pathway as a Novel Regulator of Dendritic Cell Function. In: Wallach, D., Kovalenko, A., Feldmann, M. (eds) Advances in TNF Family Research. Advances in Experimental Medicine and Biology, vol 691. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6612-4_37
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