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The Edar Subfamily in Hair and Exocrine Gland Development

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Advances in TNF Family Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 691))

Abstract

The Edar subfamily of TNFRs includes three receptors, Edar, Troy, and Xedar, with similar extracellular but unrelated intracellular domains. All three receptors are expressed in the embryonic ectoderm and/or its appendages, such as hair follicle, tooth, and sweat and mammary gland. While the function of the Edar pathway, mutated in human hypohidrotic ectodermal syndrome (HED), has been conserved during vertebrate evolution, considerably less is known about the physiological role of Troy and Xedar. Research on the Edar pathway has focused on hair follicle and tooth biology, but recent progress has been made in uncovering its relevance in morphogenesis of glandular appendages as well.

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Author information

Authors and Affiliations

  1. Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland

    Marja L. Mikkola

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  1. Marja L. Mikkola
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Correspondence to Marja L. Mikkola .

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Editors and Affiliations

  1. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    David Wallach

  2. Dept. Biological Chemistry, Weizmann Institute of Science, 1 Herzl Street, Rehovot, 76100, Israel

    Andrew Kovalenko

  3. Kennedy Institute of Rheumatology, Imperial College London, Aspenlea Rd. 1, London, W6 8LH, United Kingdom

    Marc Feldmann

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Mikkola, M.L. (2011). The Edar Subfamily in Hair and Exocrine Gland Development. In: Wallach, D., Kovalenko, A., Feldmann, M. (eds) Advances in TNF Family Research. Advances in Experimental Medicine and Biology, vol 691. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6612-4_3

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